Identifying a gene-regulatory network that drives fibromuscular dysplasia

Identifying a gene-regulatory network that drives fibromuscular dysplasia


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Fibromuscular dysplasia (FMD) is a poorly understood blood vessel disorder that affects up to 5% of adults. Using a systems genetics approach, we identified an FMD-associated gene


co-expression network that governs vascular cell function and developed a mouse model of FMD that recapitulates certain aspects of the human disease. Access through your institution Buy or


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taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Leadbetter,


W. F. & Burkland, C. R. Hypertension in unilateral renal disease. _J. Urol._ 39, 611–626 (1938). THIS ARTICLE PROVIDED THE FIRST DESCRIPTION OF FMD. Article  Google Scholar  * Persu, A.


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COMPLEX DISEASES. CAS  PubMed  PubMed Central  Google Scholar  Download references ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional


claims in published maps and institutional affiliations. THIS IS A SUMMARY OF: d’Escamard, V. et al. Integrative gene regulatory network analysis discloses key driver genes of fibromuscular


dysplasia. _Nat. Cardiovasc. Res_. https://doi.org/10.1038/s44161-024-00533-w (2024). RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Identifying a


gene-regulatory network that drives fibromuscular dysplasia. _Nat Cardiovasc Res_ 3, 1033–1034 (2024). https://doi.org/10.1038/s44161-024-00534-9 Download citation * Published: 13 September


2024 * Issue Date: September 2024 * DOI: https://doi.org/10.1038/s44161-024-00534-9 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get


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