
Identifying a gene-regulatory network that drives fibromuscular dysplasia
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Fibromuscular dysplasia (FMD) is a poorly understood blood vessel disorder that affects up to 5% of adults. Using a systems genetics approach, we identified an FMD-associated gene
co-expression network that governs vascular cell function and developed a mouse model of FMD that recapitulates certain aspects of the human disease. Access through your institution Buy or
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taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Leadbetter,
W. F. & Burkland, C. R. Hypertension in unilateral renal disease. _J. Urol._ 39, 611–626 (1938). THIS ARTICLE PROVIDED THE FIRST DESCRIPTION OF FMD. Article Google Scholar * Persu, A.
et al. Current progress in clinical, molecular, and genetic aspects of adult fibromuscular dysplasia. _Cardiovasc. Res._ 118, 65–83 (2022). THIS IS A RECENT REVIEW ARTICLE ON FMD. Article
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Commun._ 12, 6031 (2021). THIS INTERNATIONAL GWAS META-ANALYSIS IDENTIFIED FIVE LOCI ASSOCIATED WITH FMD. Article CAS PubMed PubMed Central Google Scholar * Bjorkegren, J. L. M.,
Kovacic, J. C., Dudley, J. T. & Schadt, E. E. Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other
common complex disorders. _J. Am. Coll. Cardiol._ 65, 830–845 (2015). THIS REVIEW PROVIDES A CRITICAL LOOK AT GWASS AND ARGUES THAT SYSTEMS BIOLOGY HOLDS GREAT PROMISE FOR UNDERSTANDING
COMPLEX DISEASES. CAS PubMed PubMed Central Google Scholar Download references ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional
claims in published maps and institutional affiliations. THIS IS A SUMMARY OF: d’Escamard, V. et al. Integrative gene regulatory network analysis discloses key driver genes of fibromuscular
dysplasia. _Nat. Cardiovasc. Res_. https://doi.org/10.1038/s44161-024-00533-w (2024). RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Identifying a
gene-regulatory network that drives fibromuscular dysplasia. _Nat Cardiovasc Res_ 3, 1033–1034 (2024). https://doi.org/10.1038/s44161-024-00534-9 Download citation * Published: 13 September
2024 * Issue Date: September 2024 * DOI: https://doi.org/10.1038/s44161-024-00534-9 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get
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