Increasing survival in hcv-related hepatocellular carcinoma

Access through your institution Buy or subscribe The benefits of direct-acting antiviral (DAA) therapy for hepatitis C in patients with hepatocellular carcinoma (HCC) have been debated. In a

retrospective cohort study of 797 patients with HCV-related HCC with a complete response to HCC treatment (383 patients received DAAs, 414 patients did not), DAA therapy was associated with

a significant reduction in the risk of death (HR 0.54; 95% CI 0.33–0.90). Furthermore, this association differed by whether or not patients had achieved a sustained virologic response (SVR)

to DAA therapy, with risk of death reduced in those who had achieved SVR (HR 0.29; 95% CI 0.18–0.47), but not in those who did not achieve SVR (HR 1.13; 95% CI 0.55–2.33). This is a preview

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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Singal, A. G. et al. Direct-acting antiviral therapy for HCV

infection is associated with increased survival in patients with a history of hepatocellular carcinoma. _Gastroenterology_ https://doi.org/10.1053/j.gastro.2019.07.040 (2019) Article  PubMed

  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Gastroenterology & Hepatology http://www.nature.com/nrgastro/ Katrina Ray Authors *

Katrina Ray View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Katrina Ray. RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ray, K. Increasing survival in HCV-related hepatocellular carcinoma. _Nat Rev Gastroenterol Hepatol_ 16, 582 (2019).

https://doi.org/10.1038/s41575-019-0202-2 Download citation * Published: 20 August 2019 * Issue Date: October 2019 * DOI: https://doi.org/10.1038/s41575-019-0202-2 SHARE THIS ARTICLE Anyone

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