Jmy: actin up in cell motility

Access through your institution Buy or subscribe > “...JMY contributes to the assembly of the actin cytoskeleton and > cell motility” The authors observed a potential Arp2/3-activating

sequence, WWW.CA, in JMY. WWW.CA contains three repeats of the actin monomer-binding domain WH2, in addition to a domain that can bind actin and Arp2/3. Intriguingly, _in vitro_, JMY can

both activate Arp2/3 and, in the absence of Arp2/3, induce rapid actin polymerization. JMY produces branched filaments in the presence of Arp2/3, which is consistent with Arp2/3-mediated

nucleation, but it also nucleates unbranched filaments in the absence of Arp2/3, which is consistent with spire-induced nucleation. Thus, JMY seems to combine the nucleating activities of

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PAPER * Zuchero, J. B. et al. p53-cofactor JMY is a multifunctional actin nucleation factor. _Nature Cell Biol._ 15 Mar 2009 (doi:10.1038/ncb1852) Article  CAS  PubMed  PubMed Central 

Google Scholar  FURTHER READING * Goley, E. D. & Welch, M.D. The ARP2/3 complex: an actin nucleator comes of age. _Nature Rev. Mol. Cell Biol._ 7, 713–726 (2006) Article  CAS  Google

Scholar  Download references Authors * Katharine H. Wrighton View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wrighton, K. JMY: actin up in cell motility. _Nat Rev Mol Cell Biol_ 10, 304 (2009). https://doi.org/10.1038/nrm2678 Download citation *

Published: 02 April 2009 * Issue Date: May 2009 * DOI: https://doi.org/10.1038/nrm2678 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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