In Brief | Nature Reviews Molecular Cell Biology

Access through your institution Buy or subscribe DEGRADATION-MEDIATED PROTEIN QUALITY CONTROL IN THE NUCLEUS. Gardner, R. G. _et al_. _Cell_ 120, 803–815 (2005) The authors identified a

quality control system for nuclear proteins in budding yeast that is defined by San1, a ubiquitin-protein ligase that requires nuclear localization for its proper function. In conjunction

with the ubiquitin-conjugating enzymes Cdc34 and Ubc1, San1 specifically targets mutant proteins, but not their wild-type counterparts, for ubiquitylation and proteasome-mediated

degradation. So, San1 functions as a proteolytic defence system against aberrant nuclear proteins. This is a preview of subscription content, access via your institution ACCESS OPTIONS

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6, 359 (2005). https://doi.org/10.1038/nrm1658 Download citation * Issue Date: 01 May 2005 * DOI: https://doi.org/10.1038/nrm1658 SHARE THIS ARTICLE Anyone you share the following link with

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