Combining ox40l and mtor blockade
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Access through your institution Buy or subscribe Controlling alloimmunity after transplantation remains a significant challenge, as existing immunosuppressive agents typically inhibit both
effector T (Teff) and regulatory T (Treg) cells. Using the non-human primate graft-versus-host disease (GVHD) model, Tkachev _et al_. now demonstrate that the combination of the mTOR
inhibitor sirolimus with an antibody against the tumour necrosis factor superfamily member OX40L (KY1005) synergistically controls T cell activation after haematopoietic stem cell
transplantation while permitting robust regulatory T cell reconstitution. This results in prolonged GVHD-free survival of more than 100 days. This is a preview of subscription content,
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SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about
institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Tkachev, V. et al. Combined OX40L and mTOR blockade controls effector T cell activation while preserving
Treg reconstitution after transplant. _Sci. Transl Med._ 9, eaan3085 (2017)10.1126/scitranslmed.aan3085 Article CAS PubMed PubMed Central Google Scholar Download references Authors *
Sarah Crunkhorn View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE
Crunkhorn, S. Combining OX40L and mTOR blockade. _Nat Rev Drug Discov_ 16, 754 (2017). https://doi.org/10.1038/nrd.2017.207 Download citation * Published: 30 October 2017 * Issue Date:
November 2017 * DOI: https://doi.org/10.1038/nrd.2017.207 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable
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