Combining ox40l and mtor blockade

Access through your institution Buy or subscribe Controlling alloimmunity after transplantation remains a significant challenge, as existing immunosuppressive agents typically inhibit both

effector T (Teff) and regulatory T (Treg) cells. Using the non-human primate graft-versus-host disease (GVHD) model, Tkachev _et al_. now demonstrate that the combination of the mTOR

inhibitor sirolimus with an antibody against the tumour necrosis factor superfamily member OX40L (KY1005) synergistically controls T cell activation after haematopoietic stem cell

transplantation while permitting robust regulatory T cell reconstitution. This results in prolonged GVHD-free survival of more than 100 days. This is a preview of subscription content,

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institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Tkachev, V. et al. Combined OX40L and mTOR blockade controls effector T cell activation while preserving

Treg reconstitution after transplant. _Sci. Transl Med._ 9, eaan3085 (2017)10.1126/scitranslmed.aan3085 Article  CAS  PubMed  PubMed Central  Google Scholar  Download references Authors *

Sarah Crunkhorn View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE

Crunkhorn, S. Combining OX40L and mTOR blockade. _Nat Rev Drug Discov_ 16, 754 (2017). https://doi.org/10.1038/nrd.2017.207 Download citation * Published: 30 October 2017 * Issue Date:

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