Vitiligo following stem-cell transplant

ABSTRACT Vitiligo is an acquired skin disorder characterised by depigmentation of skin due to the selective destruction of melanocytes. The pathogenesis of vitiligo is still relatively

unknown, but associations between vitiligo and other systemic autoimmune diseases have been made, such as with patients who have undergone haematopoietic stem cell transplantation (HSCT) in

the treatment of haematological conditions. This article aims to review published literature that have reported the incidence of vitiligo following HSCT in order to understand their

relationship, and any potential connections between vitiligo and graft-versus-host disease (GVHD). On the 21st of May 2017, the databases Pubmed, EMBASE and SCOPUS were searched using the

search terms _Stem cell_ or _transplant_ or _GVHD_ AND _vitiligo_ or _leucoderma_ or _leucoderma_. There was a total of 38 cases (from 28 case report articles) along with 9 cohort studies

that were included in the review. The studies reviewed showed that the incidence of vitiligo in patients who have received HSCT is higher than that of the normal population. Current studies

are largely limited to single-case reports, which have certain inconsistencies with regard to patient/donor profiling, and future studies should look to address these issues. Access through

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CONTENT BEING VIEWED BY OTHERS PROSPECTIVE PILOT TRIAL OF CALCIPOTRIENE AS A NOVEL TOPICAL TREATMENT FOR ACUTE SKIN GRAFT VERSUS HOST DISEASE Article 08 January 2021 ASSOCIATION OF MULTIPLE

SCLEROSIS WITH VITILIGO: A SYSTEMATIC REVIEW AND META-ANALYSIS Article Open access 20 October 2020 UNDERSTANDING AND TREATMENT OF CUTANEOUS GRAFT-VERSUS-HOST-DISEASE Article 20 September

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references AUTHOR INFORMATION Author notes * These authors contributed equally: Alessio Totani, Hossam Amin AUTHORS AND AFFILIATIONS * Faculty of Health and Medical Sciences, The University

of Adelaide, Adelaide, SA, Australia Alessio Totani, Hossam Amin & Ian Lewis * Royal Adelaide Hospital, Adelaide, SA, Australia Stephen Bacchi Authors * Alessio Totani View author

publications You can also search for this author inPubMed Google Scholar * Hossam Amin View author publications You can also search for this author inPubMed Google Scholar * Stephen Bacchi

View author publications You can also search for this author inPubMed Google Scholar * Ian Lewis View author publications You can also search for this author inPubMed Google Scholar

CORRESPONDING AUTHOR Correspondence to Alessio Totani. ETHICS DECLARATIONS CONFLICT OF INTEREST The authors declare that they have no conflict of interest. ADDITIONAL INFORMATION PUBLISHER’S

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ARTICLE CITE THIS ARTICLE Totani, A., Amin, H., Bacchi, S. _et al._ Vitiligo following stem-cell transplant. _Bone Marrow Transplant_ 55, 332–340 (2020).

https://doi.org/10.1038/s41409-019-0626-x Download citation * Received: 03 December 2018 * Revised: 23 April 2019 * Accepted: 26 May 2019 * Published: 29 July 2019 * Issue Date: February

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