The Spindle at Metaphase | Nature

ABSTRACT OSTERGREN1 suggested that, before and during metaphase, the mitotic and meiotic chromosomes are subjected to pole-directed forces α, which orient the chromosomes at the equator of

the spindle and separate them at anaphase. He also postulated a centrifugal force, γ, moving the chromosomes to the periphery of the metaphase plate; but he could suggest no physical

explanation for γ. McIntosh _et al._2 developed Ostergren's hypothesis, but failed to account for several important features of mitotic and meiotic spindles, including γ. Access through

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FORCE-TRANSDUCING MOLECULAR ENSEMBLES AT GROWING MICROTUBULE TIPS CONTROL MITOTIC SPINDLE SIZE Article Open access 14 November 2024 REFERENCES * Ostergren, G., _Hereditas_, 37, 85 (1951).

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THIS ARTICLE GAWADI, N. The Spindle at Metaphase. _Nature_ 232, 61–62 (1971). https://doi.org/10.1038/232061a0 Download citation * Received: 16 November 1970 * Issue Date: 02 July 1971 *

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