Pharmacology of some marijuana constituents and two heterocyclic analogues

ABSTRACT THERE have been few reports concerning the chemistry and pharmacology of marijuana and its constituents1,2, and most investigators have studied the natural product or a crude

extract. Mechoulam and co-workers3 isolated Δ9-tetrahydrocannabinol, which is believed to be the most active constituent of marijuana and has been shown to have marijuana-like activity in

man4. Subsequently, Δ8-tetrahydrocannabinol was purified and now both isomers have been prepared synthetically and are available in small quantities for pharmacological experimentation.

These substances are somewhat unique in that there are few agents which have such a profound effect on the central nervous system yet do not contain either a sulphur or nitrogen atom in the

molecule. We report here some preliminary pharmacological results with pure synthetic Δ8 and Δ9-tetrahydrocannabinol (Δ9-THC), and also describe the effect of the insertion of a heterocyclic

atom in ring C on the pharmacology of these agents. The nitrogen analogue of Δ9-THC (I in Fig. 1) was synthesized by Pars and co-workers5 and the sulphur analogue (II) by R. K. R.

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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF THE EPIMERS OF HEXAHYDROCANNABINOL (HHC) Article Open access 08 July 2023

IDENTIFICATION OF A NEW CANNABIDIOL N-HEXYL HOMOLOG IN A MEDICINAL CANNABIS VARIETY WITH AN ANTINOCICEPTIVE ACTIVITY IN MICE: CANNABIDIHEXOL Article Open access 16 December 2020 IN VITRO AND

IN VIVO PHARMACOLOGICAL ACTIVITY OF MINOR CANNABINOIDS ISOLATED FROM _CANNABIS SATIVA_ Article Open access 23 November 2020 REFERENCES * _Cannabis Bibliography_ (United Nations Economic and

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Medicine, University of North Carolina, Chapel Hill, North Carolina, 27514 WILLIAM L. DEWEY, LOUIS S. HARRIS, JOHN F. HOWES & J. STEPHEN KENNEDY * Arthur D. Little, Inc., Acorn Park,

Cambridge, Massachusetts, 02140 FELIX E. GRANCHELLI, HARRY G. PARS & RAJ K. RAZDAN Authors * WILLIAM L. DEWEY View author publications You can also search for this author inPubMed Google

Scholar * LOUIS S. HARRIS View author publications You can also search for this author inPubMed Google Scholar * JOHN F. HOWES View author publications You can also search for this author

inPubMed Google Scholar * J. STEPHEN KENNEDY View author publications You can also search for this author inPubMed Google Scholar * FELIX E. GRANCHELLI View author publications You can also

search for this author inPubMed Google Scholar * HARRY G. PARS View author publications You can also search for this author inPubMed Google Scholar * RAJ K. RAZDAN View author publications

You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE DEWEY, W., HARRIS, L., HOWES, J. _et al._

Pharmacology of some Marijuana Constituents and Two Heterocyclic Analogues. _Nature_ 226, 1265–1267 (1970). https://doi.org/10.1038/2261265a0 Download citation * Received: 24 October 1969 *

Revised: 03 February 1970 * Issue Date: 27 June 1970 * DOI: https://doi.org/10.1038/2261265a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:

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