Why we need to keep an eye on whether a blood infection in cattle is linked to breast cancer in humans

Meredith Frie receives funding from the U.S. Department of Agriculture, Michigan State University AgBioResearch, and the Michigan Milk Producers Association.

Humans began domesticating animals for food over 10,000 years ago, cultivating a close relationship with animals over the following millennia. Like humans, animals can get sick, and

sometimes infections pass between humans and animals. Some of these infections, like ringworm, are mostly harmless, while others, like bovine tuberculosis, are extremely serious.

But how do we find out if these infections pose a risk to humans? I study dairy cows infected with bovine leukemia virus (BLV), which is found in most of the dairy herds in the U.S.

Scientists are trying to figure out if BLV infects humans and, if it does, whether there is a link between BLV and breast cancer.

This kind of research is not only a great example of how scientists monitor health risks in our food supply, but also why it’s critical to revisit, and maybe revise, older scientific

conclusions as new and improved technologies become available.

When BLV was first discovered in the late 1960s, scientists set out to learn more about it, including the possibility of BLV infection in humans. Based on the scientific techniques available

at the time, it was determined that BLV was not a risk to cattle or human health.

But with a shift from small farms to industrialized agriculture, BLV infection rates have skyrocketed since the 1960s. Today in the U.S., BLV is present in 83 percent of dairy herds, and

almost 40 percent of all dairy cows are infected. BLV is also present in 39 percent of U.S. beef herds.

The average American consumes almost 620 pounds of dairy and over 50 pounds of beef every year.

Given the increase in BLV infections, American diets and major advances in scientific technology allowing for greater detection of BLV, researchers decided it was time to revisit whether BLV

poses any risk to humans.

A 2003 study from researchers at UC Berkeley, led by Gertrude Buehring, used newer, highly sensitive techniques to test 257 human blood samples, finding antibodies for BLV in 74 percent of

them.

So what does that mean? Antibodies can develop against a virus whether it is alive or dead. But, only a live virus can infect and replicate within cells, causing illness. This study told us

that humans are exposed to BLV, but not if humans are getting infected with live BLV.

The most probable way people are exposed to BLV is by consuming the milk or meat of infected cows. Since BLV is a blood-borne virus that is transmitted through bodily fluids, transmission

through consumption is not likely, though not impossible.

Infected mothers (both humans and cows) can transmit these types of viruses to their babies when nursing, but this type of transmission would probably not happen to adults. And in the event

that BLV could infect adults after ingestion, cooking or pasteurization would kill the virus anyway.

However, consuming pasteurized milk could provide exposure to dead BLV, which could explain the presence of antibodies against BLV in our blood. Although research hasn’t investigated whether

BLV can be found in meat, it is possible.

The antibody data from Dr. Buehring’s study showed that we are likely exposed to BLV, either live or dead, and these results merit revisiting a scientific question previously considered

settled. Could BLV infect and replicate within human cells?

Unfortunately, the research on this question has provided conflicting answers.

The Buehring group, which found BLV antibodies in humans, published research in 2015 reporting that BLV had been found in cancerous human breast tissue.

Specifically, they found BLV DNA (indicating infection) in 29 percent of healthy breast tissues and in 59 percent of cancerous breast tissues analyzed. But BLV protein, which suggests

replication, was detected in only 6 percent of samples – too few to determine if the protein was more prevalent in cancerous breast tissue. However, BLV DNA was highly associated with

cancerous tissue over healthy tissue. This association would suggest that BLV is in someway related to, perhaps even causing, breast cancer.

In a separate publication, the Buehring group found BLV DNA in 44 percent of 219 breast tissue samples, suggesting that BLV does infect humans.

Researchers in Belgium examined 51 breast cancer tissue samples for BLV DNA, but they found none. Another study conducted by the Thiel research group in 2007 looked for BLV DNA in cancerous

T cell (blood cancer) samples, which are caused by a close viral relative of BLV. However, they didn’t find any BLV DNA in the samples they examined.

The Su team at the University of Texas broadly probed for active viruses within a wide range of malignant cancers (including breast cancer), and they didn’t find evidence of any viral

activity in the breast cancer samples, including BLV. This contradicts the Buehring results that showed 6 percent of tumor samples with BLV protein.

Previous research has also investigated whether dairy consumption was linked to breast cancer, including the consumption of unpasteurized milk. These studies found no relationship between

milk consumption and breast cancer, and one would expect a relationship if BLV were causing breast cancer.

BLV does not cause breast cancer in cows, although BLV has been detected in bovine mammary tissue. Instead, BLV causes leukemia or lymphoma, which are blood cancers, and only about 5 percent

or fewer BLV-infected cows will develop cancer. That could be related to their short lifespan – dairy cows are usually slaughtered for meat around 4-5 years of age.

New research suggests that BLV infection in dairy cows has more negative effects than previously appreciated.

BLV-infected cows produce less milk and have shorter lifespans. It’s likely that BLV infection impairs their immune system, and a healthy immune system is essential to the well-being and

productivity of dairy cows.

Even if BLV isn’t a risk to human health, studying it remains important because of the risk it poses to dairy cattle.

Here’s what we know: Humans are probably exposed to BLV through the meat and dairy consumed from infected cattle, but we don’t know whether we are exposed to live or dead BLV. If we are

exposed to live BLV, it’s likely due to consuming raw milk products or undercooked meat. And if we are getting infected with BLV, it could possibly increase the risk of getting breast

cancer, according to one study.

Today the research suggests that BLV isn’t a risk to humans. But, if you are worried, avoid unpasteurized dairy products and make sure your meat is fully cooked – and these are important

practices for staying healthy anyway.

While the current scientific literature suggests that BLV isn’t a risk to humans, the question about BLV and its risk to humans illustrates an important principle of science – and of the

relationship between human and animal health.

Animal agriculture has existed for 10,000 years, and BLV was discovered only 40 years ago. Our scientific knowledge expands every day due to improved technologies and increased understanding

of the world. Often, this means that we need to refine, or even revise, previously held scientific truths.