Nature reviews rheumatology - volume 9 issue 3, march 2013

RATIONAL THERAPY IN RA Late twentieth century progress in DMARD therapy for rheumatoid arthritis (RA) has been complemented in this millennium by the advent of targeted biologic therapy and

novel small-molecule drugs. Amid this seeming progress, however, results for individual patients are often disappointing. These five specially commissioned Reviews and one News & Views

article, written by key opinion leaders in research and clinical practice, summarize emerging insights into the underlying basis of RA, how best to use existing therapies, new treatment

targets and progress in targeting them, and how to gain maximum benefit from the opportunities afforded by clinical trials of new agents.