The goldilocks oxygen principle: not too little and not too much

Nature has evolved creative ways to maintain oxygen homeostasis, but what happens when these adaptations are insufficient? Here we discuss biochemical failure points across the oxygen

spectrum from ‘too little’ to ‘too much’ oxygen and their potential contributions to cardiovascular disease. Access through your institution Buy or subscribe This is a preview of

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ACKNOWLEDGEMENTS I.H.J. was supported by US National Institutes of Health (NIH) DP5 DP5OD026398. W.R.F. was supported by NIH R01AG065428. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Gladstone Institutes, San Francisco, CA, USA Will R. Flanigan & Isha H. Jain * UCSF-UC Berkeley Joint PhD Program in Bioengineering, Berkeley, CA, USA Will R. Flanigan * Department of

Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA Isha H. Jain * Cardiovascular Research Institute, University of California, San Francisco, San

Francisco, CA, USA Isha H. Jain Authors * Will R. Flanigan View author publications You can also search for this author inPubMed Google Scholar * Isha H. Jain View author publications You

can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Isha H. Jain. ETHICS DECLARATIONS COMPETING INTERESTS I.H.J. is a consultant for Maze

Therapeutics. W.R.F. declares no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Flanigan, W.R., Jain, I.H. The Goldilocks Oxygen

Principle: not too little and not too much. _Nat Cardiovasc Res_ 1, 1101–1103 (2022). https://doi.org/10.1038/s44161-022-00178-7 Download citation * Published: 12 December 2022 * Issue Date:

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