Nuclear remodeling drives age-related cardiac dysfunction

We found that aging is accompanied by a reduction in cardiomyocyte nuclear size and increased stiffness, dependent on loss of A-type lamins. Mechanistically, age-dependent nuclear remodeling

represses expression of cardiogenic transcription factors that are required for heart contractility. Preserving lamin or transcription factors delays cardiac decline. Access through your

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Rabinovitch, P. S. The aging heart. _Cold Spring Harb. Perspect. Med._ 5, 1–15 (2015). A REVIEW ARTICLE THAT DESCRIBES THE MECHANISMS OF AGE-DEPENDENT HEART DYSFUNCTION. Article  CAS  Google

Scholar  * Kirby, T. J. & Lammerding, J. Emerging views of the nucleus as a cellular mechanosensor. _Nat. Cell Biol._ 20, 373–381 (2018). A REVIEW ARTICLE THAT DESCRIBES

MECHANOTRANSDUCTION AND THE ROLE OF THE NUCLEUS. Article  CAS  Google Scholar  * Ho, R. & Hegele, R. A. Complex effects of laminopathy mutations on nuclear structure and function.

_Clinical Genetics_ 95, 199–209 (2019). A REVIEW ARTICLE THAT DESCRIBES THE MECHANISMS OF AGE DEPENDENT HEART DYSFUNCTION. Article  CAS  Google Scholar  * Zhao, H. et al. Destabilizing

heterochromatin by APOE mediates senescence. _Nat. Aging_ 2, 303–316 (2022). A RESEARCH ARTICLE THAT PRESENTS A MECHANISM OF AGE-RELATED LAMIN A/C LOSS BY APOE-DEPENDENT AUTOPHAGY. Article 

Google Scholar  * Scaffidi, P. & Misteli, T. Lamin A-dependent nuclear defects in human aging. _Science_ 312, 1059–1063 (2006). A RESEARCH ARTICLE THAT DEMONSTRATES CONSERVED NUCLEAR

REMODELING IN PROGERIA SYNDROME AND AGED DONOR FIBROBLASTS. Article  CAS  Google Scholar  Download references ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with

regard to jurisdictional claims in published maps and institutional affiliations. THIS IS A SUMMARY OF: Kirkland, N. J. et al. Age-dependent Lamin changes induce cardiac dysfunction via

dysregulation of cardiac transcriptional programs. _Nat. Aging_, https://doi.org/10.1038/s43587-022-00323-8 (2022). RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE Nuclear remodeling drives age-related cardiac dysfunction. _Nat Aging_ 3, 15–16 (2023). https://doi.org/10.1038/s43587-022-00324-7 Download citation * Published: 30 December

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