A rala between high-fat diet and mitochondrial shape

High-fat diet (HFD) causes mitochondrial dysfunction in white adipocytes. A study in _Nature Metabolism_ identifies the small GTPase RalA as a culprit in mice. Upon HFD, RalA activates the

fission protein Drp1 to cause mitochondrial fragmentation and dysfunction, linking mitochondrial fuel utilization in white adipocytes to systemic lipid metabolism. Access through your

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calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Xia, W. et al. _Nat. Metab._

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National Recovery and Resilience Plan, Mission 4 ‘Education and Research’ — Component 2 ‘From Research to Enterprise’ — Investment 1.3, funded by the European Union — NextGenerationEU.

AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Biology, University of Padova, Padova, Italy Ludovica Zambello & Luca Scorrano * Veneto Institute of Molecular Medicine,

Padova, Italy Ludovica Zambello & Luca Scorrano Authors * Ludovica Zambello View author publications You can also search for this author inPubMed Google Scholar * Luca Scorrano View

author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Luca Scorrano. ETHICS DECLARATIONS COMPETING INTERESTS The authors

declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Zambello, L., Scorrano, L. A RalA between high-fat diet and mitochondrial

shape. _Nat Metab_ 6, 198–199 (2024). https://doi.org/10.1038/s42255-023-00969-7 Download citation * Published: 29 January 2024 * Issue Date: February 2024 * DOI:

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