Assessing health-related quality of life of people with diabetes in nigeria using the eq-5d-5l: a cross-sectional study

ABSTRACT Assessing the health-related quality of life (HRQoL) of people with diabetes is important to evaluate treatment effectiveness and identify interventions that would be beneficial to

the patients. This descriptive cross-sectional study aimed to assess the HRQoL of people with diabetes visiting 15 community pharmacies in Akwa Ibom State, Nigeria, and to identify its

determinants. The English (Nigeria) version of the EQ-5D-5L was administered to 420 eligible patients between August and September 2021. Data were analyzed with SPSS (IBM version 25.0) and

presented descriptively; differences in HRQoL scores were examined using inferential statistics. Statistical significance was set at _p_ < 0.05. Most participants (56.8%) were female; 193

(49.6%) were between the ages of 30 and 49. The median (interquartile range, IQR) for the EQ VAS and EQ-5D-5L index scores, respectively, were 80.0 (65.0–85.0) and 0.77 (0.62–0.90). Most

participants reported problems with usual activities (52.7%), pain/discomfort (60.2%), and anxiety/depression (57.6%). The EQ VAS score and EQ-5D-5L utility index were significantly (_p_ 

< 0.05) associated with respondents' age, marital status, work status, and personal monthly income. The HRQoL of participants was relatively high. Nevertheless, implementing

strategies aimed at pain management and providing psychological support for people with diabetes in Nigeria may improve their HRQoL. SIMILAR CONTENT BEING VIEWED BY OTHERS HEALTH STATUS

BASED ON EQ-5D-5L FOR THE CANCER PATIENT POPULATION IN MALAYSIA Article Open access 08 April 2024 ESTIMATING POPULATION NORMS FOR THE HEALTH-RELATED QUALITY OF LIFE OF ADULTS IN SOUTHERN

JIANGSU PROVINCE, CHINA Article Open access 14 June 2022 A HEAD-TO-HEAD COMPARISON OF WELL-BEING OF OLDER PEOPLE (WOOP) AND EQ-5D-5L IN PATIENTS, CARERS AND GENERAL PUBLIC IN CHINA Article

Open access 17 April 2023 INTRODUCTION Diabetes is one of the fastest growing global health emergencies of the twenty-first century1. According to the International Diabetes Federation1,

there were about 537 million people with diabetes globally in 2021; this figure is projected to rise to 643 million by 2030 and to 783 million by 2045, indicating a 46% global increase in

prevalence. In Africa, about 24 million adults were living with the disease in 2021. This figure is projected to rise to about 55 million by the year 2045, suggesting a 134% increase, making

Africa the region with the world’s fastest growing diabetes rate1. A meta-analysis by Uloko et al. reported a diabetes prevalence of 5.77% in Nigeria2. This suggests that 11.2 million

Nigerians were living with the disease in 2017 based on the country’s 193.3 million population as of September 20173. The south-south geopolitical zone of the country had the highest

diabetes prevalence, 9.8%, according to the meta-analysis2. Diabetes poses a serious global threat to the health and well-being of individuals affected, their families and nations at large1.

People living with diabetes are at risk of developing a range of debilitating and life-threatening complications, leading to a reduced (health-related) quality of life and premature death1.

Hays and Reeve define health-related quality of life (HRQoL) as how well an individual functions in their daily life as well as their perceived well-being in physical, mental and social

health domains4. In contrast to the functional component of HRQoL which consists of behaviours that can be observed by others, the well-being component refers to internal, subjective

perceptions like vitality, pain, anxiety, depressive symptoms, and general health perceptions4. HRQoL is an important patient-reported outcome which is increasingly being used to evaluate

the effect of a medical intervention on a symptom or function or a group of symptoms or functions5. It is a relevant input to conduct health economic evaluations and identify cost-effective

interventions that lead to efficient allocation of scarce resources6. Assessment of HRQoL can foster patient engagement with care and enhance a patient-centered approach to treatment5. This

is because findings from HRQoL studies can identify subgroups with relatively poor perceived HRQoL and help to guide interventions to enhance their situations and avert more serious

consequences7. Instruments used to measure HRQoL may be specific or generic. Specific instruments focus on a particular disease, population, functional area or problem/condition, while

generic instruments can be used in any population, regardless of disease or intervention5,8. Generic instruments include health profiles and utility measures8,9. Health profiles generate

scores in a variety of health domains. Utility measures incorporate preference weights or ‘utilities’—typically obtained from a representative sample of the general population—which

summarize HRQoL as a single number (index score). These index scores typically range from less than 0 (where 0 is the value of a health state equivalent to dead; negative values indicate

health states considered worse than dead) to 1 (the value of full health), with higher scores suggesting higher (better) health utility8,10. Utilities obtained from generic preference-based

measures, such as the EQ-5D-5L, can be combined with survival to generate quality adjusted life years (QALYs). QALY is a metric used in health economic evaluations (cost-utility analyses) of

treatment interventions11. Reimbursement agencies such as the National Institute for Health and Care Excellence (NICE) routinely perform cost-utility analyses for new health care

interventions12. Studies assessing the HRQoL of people with diabetes using the EQ-5D-5L in Nigeria are scant. Moreover, no study has been conducted in the south-south zone of the country

where diabetes is most prevalent. Hence, the present study aimed to evaluate the HRQoL of people with diabetes visiting some community pharmacies in Uyo, Akwa Ibom State, Nigeria, and to

explore its determinants. METHODS This study sought to assess the HRQoL of people with diabetes visiting 15 community pharmacies in Uyo, Akwa Ibom State, and to explore its determinants

using a descriptive cross sectional study. To select the study settings, Uyo metropolis was divided into three clusters: high, mid, and low, based on population distribution. From each of

these clusters, five community pharmacies were selected by convenience, for a total of 15 pharmacies. The minimum sample size required for this study was estimated to be 377 using a 95%

confidence level, a 5% margin of error, and an estimated population of 20,000 (since the population of people with diabetes in Uyo metropolis is unknown). The sample size was computed with

the aid of an online sample size calculator13. To accommodate a possible non-response of 10%, 420 respondents were targeted for the study. The estimated sample size of 420 respondents was

distributed proportionately across the selected 15 community pharmacies. Adults (18 years of age or older) with type 1 or type 2 diabetes who had been using medication(s) for diabetes for at

least six months were included in the study. Participants and/or their legal guardian(s) also had to have given informed consent to participate. INSTRUMENT FOR DATA COLLECTION The English

(Nigeria) paper self-complete five-level version of the EuroQol five-dimensional instrument (EQ- 5D-5L) was used to assess patient HRQoL. The EQ-5D-5L is a widely used generic

preference-based self-reported measure of health status consisting of two parts—the descriptive system and a visual analogue scale (VAS)10. In the descriptive system, five dimensions of

health are evaluated: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. For each of these dimensions, there are five levels of response: no problems (level 1),

slight problems (level 2), moderate problems (level 3), severe problems (level 4), and extreme problems/unable to (level 5). This section of the EQ-5D-5L offers a descriptive profile that

can be utilized to generate a (5-digit) health state profile. An individual in health state 12345, for instance, would have no problems with mobility, slight problems with self-care,

moderate problems with performing usual activities, severe pain or discomfort, and extreme anxiety or depression10. The EQ-5D-5L has a total of 3 125 (i.e. 55) potential unique health

states. Each of these health states has a corresponding utility value or index score obtained from an existing set of country/region specific preference weights14. These preference weights

or value sets reflect, on average, the general population’s preferences about the value of the health state i.e. how good or bad it is on a scale anchored at 1 (a state of full health) and 0

(a state equivalent to dead). Values less than 0 represent health states considered to be worse than dead10. The second part of the instrument—the EQ VAS—is an overall health status scale.

It allows the individual to rate the condition of their health on the day of questionnaire completion from 0 (the worst imaginable health) to 100 (the best imaginable health).The EQ-5D-5L is

brief, cognitively undemanding, and is available in several languages10. DATA COLLECTION People with diabetes who visited any of the study settings within the study period were approached

and invited to participate in the study by the investigators or the research assistants. The status—whether they were diabetic or not—was verified by questioning individuals who presented a

prescription for (an) antidiabetic medicine(s) and/or who needed any other diabetes-related services. The objectives and methods of the study were explained to potential participants, and

oral informed consent sought from them and/or their legal guardian(s). Thereafter, the EQ-5D-5L was administered to those who met the inclusion criteria. Additionally, patient demographic

and clinical variables (gender, age, marital status, work status, personal monthly income, enrolment in health insurance, insulin use) were obtained through self-report. Completed

questionnaires were retrieved by the investigators or the research assistants after ensuring that all fields had been filled. Data collection lasted for two months (August through September

2021). DATA ANALYSIS Data were analyzed using SPSS version 25.0 (IBM Corporation, Armonk, NY, USA). Descriptive statistics was used to present data. The five levels of the EQ-5D-5L were

dichotomized into ‘no problems’ (level 1) and ‘any problems’ (levels 2, 3, 4 and 5)10. A health state index score was computed from individual health state profiles using the EQ-5D-5L

crosswalk value set for Zimbabwe15 since a value set was not available for Nigeria at the time of writing. The Zimbabwean value set was used because the health status of the Zimbabwean

general population closely approximates that of the Nigerian general population. Due to the non-normal distributions of the EQ VAS and EQ-5D-5L index scores, non-parametric tests

(Mann–Whitney and Kruskal Wallis) were used to examine the differences in these scores among patient sub-groups. The level of statistical significance was set at _p_ < 0.05. Approval to

conduct this study was obtained from the Akwa Ibom State Health Research Ethics Committee (AKHREC/22/7//21/014). Informed consent was obtained from all subjects and/or their legal

guardian(s). All methods were performed in accordance with the Declaration of Helsinki. RESULTS A total of 389 out of 420 questionnaires distributed were accurately filled and returned

yielding a response rate of 92.6%. Respondents were mostly female (56.8%); almost half (49.6%) were between the ages of 30 and 49. Two hundred and twenty-nine (58.9%) were married; only 94

(24.2%) were enrolled in the National Health Insurance Scheme (NHIS). Details of respondents’ socio-demographic and clinical characteristics are presented in Table 1. DESCRIPTION OF PATIENT

HEALTH PROFILE A total of 129 (33.2%) reported having no problems with mobility, self-care, usual activities, pain/discomfort, or anxiety/depression. More than half of the respondents

reported having no problems with mobility (52.4%) and self-care (63.0%). However, most of them reported having slight to extreme problems with usual activities (52.7%), pain/discomfort

(60.2%) and anxiety/depression (57.6%). When stratified by age, the number of problems reported in all five dimensions was observed to increase with age (Table 2). SELF-REPORTED HEALTH

STATUS AND UTILITY VALUATIONS OF RESPONDENTS The median (interquartile range, IQR) of the EQ VAS and EQ-5D-5L index scores were 80.0 (65.0–85.0) and 0.77 (0.62–0.90), respectively. Only 11

(2.8%) participants reported the best health imaginable on the EQ VAS (i.e. 100). A detailed description of the self-rated health status (EQ VAS) and utility valuations (EQ-5D-5L index

scores) of respondents, stratified by age, is given in Table 3. EFFECT OF PATIENT SOCIO-DEMOGRAPHIC CHARACTERISTICS ON EQ VAS AND UTILITY VALUATIONS As shown in Table 4, age (_p_ < 

_0.001_), marital status (_p_ < _0.001_), work status (_p_ < _0.001_) and personal monthly income (_p_ = _0.042_), respectively, influenced respondents’ EQ VAS scores. Similarly, age

(_p_ < _0.001_), marital status (_p_ < _0.001_), work status (_p_ < _0.001_) and personal monthly income (_p_ < _0.001_) influenced EQ-5D-5L index scores. DISCUSSION To the best

of our knowledge, this is the first study using the EQ-5D-5L to evaluate the HRQoL of people with diabetes mellitus visiting community pharmacies in Nigeria. The median EQ VAS score and

utility valuations (EQ-5D-5L index scores) of participants in this study were relatively high. The most commonly reported problems were with usual activities, pain/discomfort and

anxiety/depression. Patient age, marital status, work status and personal monthly income were associated with EQ VAS score and utility valuations among participants. The median EQ VAS score

obtained in our study is similar to that reported in Ethiopia16 and Saudi Arabia17, but higher than that reported in Iran6. Further, the median EQ-5D-5L utility score obtained in our study

is lower than that reported in Ethiopia16 but higher than that reported in Iran6. The disparities in these HRQoL indices might be due to variations in the countries’ demographics,

socioeconomic conditions and healthcare systems. Additionally, because preference weights used in the valuation of participants’ health states often reflect national or regional values,

these weights, and hence EQ-5D-5L index scores (utility valuations), can vary between nations and regions10. The EQ VAS, which indicates the patients' perception of their health status,

was rather high in the current study. This finding might be attributed to a number of factors: Patients generally have a propensity to overestimate their health, a factor that might

erroneously underestimate their need for medical treatment18. Furthermore, participants were people with diabetes who visited community pharmacies; as a result, they were probably more

‘stable’ than some of the patients seen in endocrinology clinics. Additionally, most of the participants were less than 50 years, and a third claimed to have no problems in any of the

EQ-5D-5L dimensions. According to a prior study, persons with diabetes over the age of 50 had problems more frequently than those who were 50 years or younger across all five dimensions of

the EQ-5D-5L19. In our study, pain/discomfort was the dimension with the most frequently reported problems, similar to prior studies16,20,21,22. The second and third most frequently reported

problems were in the dimensions of anxiety/depression and usual activities, respectively. Similar findings were reported in an earlier study conducted among people with diabetes attending a

tertiary hospital in south-east Nigeria21. In general, the number of problems our participants reported for each dimension was observed to increase with age. Age was found to be

significantly associated with EQ VAS scores and utility valuations in this study. The EQ VAS scores and utility valuations of respondents decreased with increasing age. These findings are

consistent with those of earlier studies16,21,23. Although diabetes generally has a negative impact on HRQoL, as people age, physical and mental limitations, as well as an increase in body

pain and discomfort, are more common24,25,26. A likely cause of pain and discomfort in people with diabetes, particularly in those over the age of 40 or whose disease has not been well

controlled is nerve damage. Such damage may result in numbness or even pain/discomfort that interferes with usual activities26. Additionally, the complex lifelong management of diabetes and

its chronic, progressive nature can lead to anxiety and depression over time27. Hence, the number of problems reported in the anxiety/depression dimension was observed to increase with

increasing age. Contrary to our finding, a Canadian study found that diabetes patients' HRQoL improved with age. However, the effect of age vanished when other patient characteristics

(gender, duration of diabetes, physical activity, body mass index, insulin use, ethnicity, and smoking) were taken into account28. Zare et al.6 found no statistically significant association

between age and either the EQ VAS or utility valuations. Marital status also had an impact on the EQ VAS and utility valuations of participants in this study. Participants who were widowed

or divorced had worse HRQoL than those who were single or married. In contrast to our findings, however, Zare et al. did not find any statistically significant relationship between marital

status and either the EQ VAS or utility valuations6. The relatively poor HRQoL reported by widowed/divorced participants in our study may be explained by the physical, emotional and

psychological trauma typically associated with losing a partner (via death or divorce). In this study, respondents who reported being employed had higher EQ VAS scores and utility valuations

than those who reported being unemployed or retired. Similar to this, prior studies among people with diabetes found that those who were employed had much higher EQ VAS scores and utility

valuations than those who were housewives, retired, or unemployed6,16,19,22,23. Individuals who are employed typically have better quality of life than those who are unemployed29. A

plausible explanation for this is that people who are employed are generally more satisfied with their lives than those who are unemployed since they can afford the necessities of life as

well as the resources required to effectively manage any health conditions they may have. Interestingly, comparatively higher EQ VAS scores and utility valuations were reported by

individuals with lower monthly personal incomes than those with higher monthly personal incomes. This is contrary to the findings of prior studies where participants with lower income

reported worse HRQoL compared to those with higher income17,30. A high income has been shown to improve evaluation of life but not emotional well-being31. The well-being component of HRQoL

comprises internal subjective perceptions such as vitality, pain, anxiety, depressive symptoms, and general health perceptions4. In line with our finding, Tang reported a negative

correlation between income and quality of life when other variables—the love of money and job satisfaction—were controlled32. The hidden costs of high income might include work-related

stress and work-family conflict resulting from spending more time away from family. These factors can negatively affect an individual's physical, mental, and overall quality of

life33,34. The following limitations should be taken into account when interpreting these findings: The findings of this study may not apply to all people with diabetes in Nigeria because

they were generated from community pharmacies in a particular state. Nevertheless, the study was conducted in a region of the country where diabetes is most prevalent2, and compared to a

prior similar study conducted in southeast Nigeria21, it had a relatively large sample size. Another limitation is the cross-sectional design of this study which precludes causality between

patient variables and HRQoL indices. Furthermore, we did not assess the impact of variables that could affect HRQoL, such as the presence of complications or comorbidities, participants’

smoking status, or their alcohol consumption. Finally, the use of the Zimbabwean EQ-5D-5L crosswalk value sets for valuation of participants’ health states may not have reflected the true

health state utilities of our study population. This is due to the fact that while Nigeria and Zimbabwe are both African nations, their health indices are not exactly the same. CONCLUSIONS

The HRQoL of people with diabetes surveyed at some community pharmacies in Nigeria was relatively high. The most frequently reported problems were in the dimensions of usual activities,

pain/discomfort and anxiety/depression. Patient age, marital status, work status and personal monthly income were associated with EQ VAS and utility valuations among people with diabetes

surveyed. Implementing strategies aimed at pain management and providing psychological support for people with diabetes in Nigeria, especially based on their demographic information may

improve their HRQoL. Findings of this study might be useful for future cost–utility analyses to evaluate the effect of interventions or policies aiming at enhancing diabetes care in Nigeria.

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work. _J. Organ. Behav._ 12, 39–53 (1991). Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Clinical Pharmacy and Biopharmacy, Faculty

of Pharmacy, University of Uyo, Uyo, 520271, Akwa Ibom State, Nigeria Idongesit Linus Jackson & Abam Onen Arikpo * Department of Clinical Pharmacy and Pharmacy Management, Faculty of

Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria Abdulmuminu Isah Authors * Idongesit Linus Jackson View author publications You can also search for this

author inPubMed Google Scholar * Abdulmuminu Isah View author publications You can also search for this author inPubMed Google Scholar * Abam Onen Arikpo View author publications You can

also search for this author inPubMed Google Scholar CONTRIBUTIONS I.L.J. and A.I. contributed to the conception and design of the study. A.O.A. acquired the study data. I.L.J. and A.I.

contributed to the statistical analysis and interpretation of data. A.O.A. wrote the first draft of the manuscript. I.L.J. critically revised the manuscript for important intellectual

content. All authors read and approved the final manuscript. CORRESPONDING AUTHOR Correspondence to Idongesit Linus Jackson. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no

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ARTICLE Jackson, I.L., Isah, A. & Arikpo, A.O. Assessing health-related quality of life of people with diabetes in Nigeria using the EQ-5D-5L: a cross-sectional study. _Sci Rep_ 13,

22536 (2023). https://doi.org/10.1038/s41598-023-49322-8 Download citation * Received: 16 February 2023 * Accepted: 06 December 2023 * Published: 18 December 2023 * DOI:

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