Publisher Correction: Juvenile depletion of microglia reduces orientation but not high spatial frequency selectivity in mouse V1

Download PDF Publisher Correction Open access Published: 24 January 2023 Publisher Correction: Juvenile depletion of microglia reduces orientation but not high spatial frequency selectivity

in mouse V1 Dario X. Figueroa Velez1, Miguel Arreola2, Carey Y. L. Huh2, Kim Green2,3 & …Sunil P. Gandhi2,3 Show authors Scientific Reports volume 13, Article number: 1337 (2023) Cite this

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The Original Article was published on 27 July 2022

Correction to: Scientific reports https://doi.org/10.1038/s41598-022-15503-0, published online 27 July 2022

The original version of this Article contained errors in Figure 3c and d, where the y-axis labels were incorrectly given. As a result,

Orientation Selectivity Index

now reads:

Spatial Frequency (cpd)

Orientation Selectivity Index

now reads:

Spatial Frequency (cpd)

The original Figure 3 and accompanying legend appear below.

The original Article has been corrected.

The caption to be typeset alongside it is: Microglia are not required for the developmental emergence of high spatial frequency tuning nor maintenance of normal binocularity in V1. (a)

Example visually evoked calcium signal to presentations of stimuli through the contralateral eye in adult V1. The x-axis is organized by grating direction. The y-axis is organized by

increasing grating spatial frequency. Thin and thick black lines represent individual and trial averaged traces, respectively. The blue line at 120° represents the averaged responses to

different spatial frequencies directions at the neuron’s preferred direction. This trial-averaged trace was used to generate this neuron’s spatial frequency tuning curve and peak spatial

frequency. (b) The spatial frequency tuning curve for the example neuron in (a). The peak spatial frequency for excitatory (c) and inhibitory (d) neurons. Violin plots represent the

population distribution in juvenile (grey) and adult control (blue) mice, and adults on PLX5622 chow (red). Black circles represent an animal’s mean peak spatial frequency. (c) During normal

development, excitatory neurons shift toward higher spatial frequencies (Juvenile Control = 0.08 ± 0.01 vs Adult Control = 0.12 ± 0.01, p = 0.035). The peak spatial frequency of mice fed

PLX5622 (0.16 ± 0.02) was higher than juvenile (p = 0.002) and comparable to adult control mice (p = 0.253). (d) Like their excitatory counterpart, inhibitory neurons shift toward higher

spatial frequencies during normal development (Juvenile Control = 0.08 ± 0.02 vs Adult Control = 0.15 ± 0.02, p = 0.043). The peak spatial frequency of mice fed PLX5622 (0.18 ± 0.03) was

higher than juvenile (p = 0.006) and comparable to adult control mice (p = 0.450). Histogram of ocular dominance index for excitatory (e) and inhibitory (f) neurons in juveniles (grey),

adults (blue), and mice lacking microglia (red). Microglia depletion did not alter the established binocularity of neurons in V1 (Juvenile Control = 0.45 ± 0.08 vs Adult Control = 0.30 ± 

0.08 cpd, vs Adult PLX5622 = 0.36 ± 0.11). nJuvenileControl = 9 mice, nAdultControl = 9 mice, nAdultPLX5622 = 11 mice. Error bars represent the S.E.M.

Full size image Author informationAuthors and Affiliations Department of Pathology, Children’s Hospital Boston, Boston, MA, 02115, USA

Dario X. Figueroa Velez

Department of Neurobiology and Behavior, University of California, Irvine, CA, 92697, USA

Miguel Arreola, Carey Y. L. Huh, Kim Green & Sunil P. Gandhi

Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA, 92697, USA

Kim Green & Sunil P. Gandhi

AuthorsDario X. Figueroa VelezView author publications You can also search for this author inPubMed Google Scholar

Miguel ArreolaView author publications You can also search for this author inPubMed Google Scholar

Carey Y. L. HuhView author publications You can also search for this author inPubMed Google Scholar

Kim GreenView author publications You can also search for this author inPubMed Google Scholar

Sunil P. GandhiView author publications You can also search for this author inPubMed Google Scholar

Corresponding author Correspondence to Sunil P. Gandhi.

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About this articleCite this article Velez, D.X.F., Arreola, M., Huh, C.Y.L. et al. Publisher Correction: Juvenile depletion of microglia reduces orientation but not high spatial frequency

selectivity in mouse V1. Sci Rep 13, 1337 (2023). https://doi.org/10.1038/s41598-022-27362-w

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Published: 24 January 2023

DOI: https://doi.org/10.1038/s41598-022-27362-w

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