Publisher Correction: Juvenile depletion of microglia reduces orientation but not high spatial frequency selectivity in mouse V1

Publisher Correction: Juvenile depletion of microglia reduces orientation but not high spatial frequency selectivity in mouse V1


Play all audios:

Loading...

Download PDF Publisher Correction Open access Published: 24 January 2023 Publisher Correction: Juvenile depletion of microglia reduces orientation but not high spatial frequency selectivity


in mouse V1 Dario X. Figueroa Velez1, Miguel Arreola2, Carey Y. L. Huh2, Kim Green2,3 & …Sunil P. Gandhi2,3 Show authors Scientific Reports volume 13, Article number: 1337 (2023) Cite this


article


455 Accesses


Metrics details


The Original Article was published on 27 July 2022


Correction to: Scientific reports https://doi.org/10.1038/s41598-022-15503-0, published online 27 July 2022


The original version of this Article contained errors in Figure 3c and d, where the y-axis labels were incorrectly given. As a result,


Orientation Selectivity Index


now reads:


Spatial Frequency (cpd)


Orientation Selectivity Index


now reads:


Spatial Frequency (cpd)


The original Figure 3 and accompanying legend appear below.


The original Article has been corrected.

Figure 3


The caption to be typeset alongside it is: Microglia are not required for the developmental emergence of high spatial frequency tuning nor maintenance of normal binocularity in V1. (a)


Example visually evoked calcium signal to presentations of stimuli through the contralateral eye in adult V1. The x-axis is organized by grating direction. The y-axis is organized by


increasing grating spatial frequency. Thin and thick black lines represent individual and trial averaged traces, respectively. The blue line at 120° represents the averaged responses to


different spatial frequencies directions at the neuron’s preferred direction. This trial-averaged trace was used to generate this neuron’s spatial frequency tuning curve and peak spatial


frequency. (b) The spatial frequency tuning curve for the example neuron in (a). The peak spatial frequency for excitatory (c) and inhibitory (d) neurons. Violin plots represent the


population distribution in juvenile (grey) and adult control (blue) mice, and adults on PLX5622 chow (red). Black circles represent an animal’s mean peak spatial frequency. (c) During normal


development, excitatory neurons shift toward higher spatial frequencies (Juvenile Control = 0.08 ± 0.01 vs Adult Control = 0.12 ± 0.01, p = 0.035). The peak spatial frequency of mice fed


PLX5622 (0.16 ± 0.02) was higher than juvenile (p = 0.002) and comparable to adult control mice (p = 0.253). (d) Like their excitatory counterpart, inhibitory neurons shift toward higher


spatial frequencies during normal development (Juvenile Control = 0.08 ± 0.02 vs Adult Control = 0.15 ± 0.02, p = 0.043). The peak spatial frequency of mice fed PLX5622 (0.18 ± 0.03) was


higher than juvenile (p = 0.006) and comparable to adult control mice (p = 0.450). Histogram of ocular dominance index for excitatory (e) and inhibitory (f) neurons in juveniles (grey),


adults (blue), and mice lacking microglia (red). Microglia depletion did not alter the established binocularity of neurons in V1 (Juvenile Control = 0.45 ± 0.08 vs Adult Control = 0.30 ± 


0.08 cpd, vs Adult PLX5622 = 0.36 ± 0.11). nJuvenileControl = 9 mice, nAdultControl = 9 mice, nAdultPLX5622 = 11 mice. Error bars represent the S.E.M.


Full size image Author informationAuthors and Affiliations Department of Pathology, Children’s Hospital Boston, Boston, MA, 02115, USA


Dario X. Figueroa Velez


Department of Neurobiology and Behavior, University of California, Irvine, CA, 92697, USA


Miguel Arreola, Carey Y. L. Huh, Kim Green & Sunil P. Gandhi


Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA, 92697, USA


Kim Green & Sunil P. Gandhi


AuthorsDario X. Figueroa VelezView author publications You can also search for this author inPubMed Google Scholar


Miguel ArreolaView author publications You can also search for this author inPubMed Google Scholar


Carey Y. L. HuhView author publications You can also search for this author inPubMed Google Scholar


Kim GreenView author publications You can also search for this author inPubMed Google Scholar


Sunil P. GandhiView author publications You can also search for this author inPubMed Google Scholar


Corresponding author Correspondence to Sunil P. Gandhi.

Rights and permissions


Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or


format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or


other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in


the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the


copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.


Reprints and permissions


About this articleCite this article Velez, D.X.F., Arreola, M., Huh, C.Y.L. et al. Publisher Correction: Juvenile depletion of microglia reduces orientation but not high spatial frequency


selectivity in mouse V1. Sci Rep 13, 1337 (2023). https://doi.org/10.1038/s41598-022-27362-w


Download citation


Published: 24 January 2023


DOI: https://doi.org/10.1038/s41598-022-27362-w


Share this article Anyone you share the following link with will be able to read this content:


Get shareable link Sorry, a shareable link is not currently available for this article.


Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative