Onecut2 many towards ar-independence

Access through your institution Buy or subscribe Androgen receptor (AR) dependence is a defining characteristic of many metastatic castration-resistant prostate cancers (mCRPCs), but some

aggressive tumours are AR-independent and rely on alternative transcriptional pathways. A new study has identified one cut domain family member 2 (ONECUT2) as a transcription factor that

negatively regulates AR networks and drives AR-independent transcriptional programmes in mCRPC. Transcriptomic and bioinformatic analyses in mCRPC cell line models revealed that ONECUT2

repressed AR and AR target gene expression. Importantly, ONECUT2 transcriptional activity — inferred using a bioinformatics approach — inversely correlated with an AR transcriptomic

signature in the discovery cohort, suggesting that ONECUT2 antagonizes AR and its transcriptional programme. Furthermore, multiplex immunofluorescence microscopy coupled to digital pathology

in high-grade prostate cancer tissues revealed that nuclear ONECUT2 and AR expression were inversely correlated in ONECUT2+AR+ cells. This is a preview of subscription content, access via

your institution RELEVANT ARTICLES Open Access articles citing this article. * KNOCKOUT OF ONECUT2 INHIBITS PROLIFERATION AND PROMOTES APOPTOSIS OF TUMOR CELLS THROUGH SKP2-MEDIATED P53

ACETYLATION IN HEPATOCELLULAR CARCINOMA * Cunjie Li * , Yuxin Xiao *  … Ning Deng _Cellular and Molecular Life Sciences_ Open Access 29 November 2024 ACCESS OPTIONS Access through your

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REFERENCES ORIGINAL ARTICLE * Rotinen, M. et al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. _Nat. Med._ 24, 1887–1898 (2018)

Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Urology http://www.nature.com/nrurol/ Conor A. Bradley Authors * Conor A.

Bradley View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Conor A. Bradley. RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bradley, C.A. ONECUT2 many towards AR-independence. _Nat Rev Urol_ 16, 65 (2019). https://doi.org/10.1038/s41585-018-0136-4 Download citation

* Published: 07 December 2018 * Issue Date: February 2019 * DOI: https://doi.org/10.1038/s41585-018-0136-4 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

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