Liver–bone crosstalk implicated in osteoporosis progression

Access through your institution Buy or subscribe Osteoporosis is a disease characterized by a low level of bone formation (by osteoblasts) and an excess of bone resorption (by osteoclasts),

in part due to increased differentiation of osteoclasts from their precursor cells, bone marrow-derived monocytes (BMDMs). A new study finds that deficiency in the deacetylase SIRT2 in

hepatocytes reduces bone loss in mouse models of osteoporosis. They then generated a liver-specific knockout of SIRT2 (_SIRT2_-KOhep mice). Aged _SIRT2_-KOhep mice had statistically

significantly higher bone mass than age-matched controls. Additionally, _SIRT2_-KOhep mice had lower serum levels of C-terminal telopeptide for type 1 collagen, a marker of bone turnover,

and lower numbers of osteoclasts than controls. The researchers then co-cultured BMDMs in vitro with plasma from either _SIRT2_-KOhep mice or control mice; the culture was treated with the

cytokines M-CSF and RANKL to induce osteoclast differentiation. Plasma from _SIRT2_-KOhep mice suppressed RANKL-induced osteoclastogenesis, as shown by the reduced number and size of

osteoclasts and reduced expression of key markers of osteoclastogenesis compared with the control co-cultures. This is a preview of subscription content, access via your institution ACCESS

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FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Lin, L. et al. SIRT2 regulates extracellular vesicle-mediated liver–bone communication. _Nat. Metab._

https://doi.org/10.1038/s42255-023-00803-0 (2023) Article  PubMed  PubMed Central  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews

Endocrinology http://www.nature.com/nrendo/ Olivia Tysoe Authors * Olivia Tysoe View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR

Correspondence to Olivia Tysoe. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Tysoe, O. Liver–bone crosstalk implicated in osteoporosis progression.

_Nat Rev Endocrinol_ 19, 440 (2023). https://doi.org/10.1038/s41574-023-00859-8 Download citation * Published: 31 May 2023 * Issue Date: August 2023 * DOI:

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