The liberating force of ultrasound

Sophisticated drug delivery systems are as essential to modern medicine as drugs themselves. Now, polymer mechanochemistry in sonicated solutions has been used to activate drugs in three

different systems. These results offer a promising approach that can be tailored to diverse molecular structures of modern pharmaceuticals. Access through your institution Buy or subscribe

This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our

best-value online-access subscription $32.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue

Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL

ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support CHANGE HISTORY * _ 13 MAY 2021 A Correction to this paper has been published:

https://doi.org/10.1038/s41557-021-00700-7 _ REFERENCES * Tibbitt, M. W., Dahlman, J. E. & Langer, R. _J. Am. Chem. Soc._ 138, 704–717 (2016). Article  CAS  Google Scholar  * Park, J.

H., Saravanakumar, G., Kim, K. & Kwon, I. C. _Adv. Drug Del. Rev._ 62, 28–41 (2010). Article  CAS  Google Scholar  * Huo, S. et al. _Nat. Chem_.

https://doi.org/10.1038/s41557-020-00624-8 (2020). * Carovac, A., Smajlovic, F. & Junuzovic, D. _Acta Inform. Med._ 19, 168–171 (2011). Article  Google Scholar  * Mason, T. J., Riera,

E., Vercet, A. & Lopez-Buesa, P. in _Emerging Technologies for Food Processing_ (ed. Da-Wen Sun) Ch. 13, 323–351 (Academic Press, 2005). * Akbulatov, S. & Boulatov, R. _ChemPhysChem_

18, 1422–1450 (2017). Article  CAS  Google Scholar  * Overington, J. P., Al-Lazikani, B. & Hopkins, A. L. _Nat. Rev. Drug Disc._ 5, 993–996 (2006). Article  CAS  Google Scholar  *

Akbulatov, S. et al. _Science_ 357, 299–303 (2017). Article  CAS  Google Scholar  * Lin, Y., Kouznetsova, T. B. & Craig, S. L. _J. Am. Chem. Soc._ 142, 99–103 (2020). Article  CAS 

Google Scholar  * Hu, X., Zeng, T., Husic, C. C. & Robb, M. J. _J. Am. Chem. Soc._ 141, 15018–15023 (2019). Article  CAS  Google Scholar  * Pan, Y. et al. _Angew. Chem. Int. Ed._ 59,

21980–21985 (2020). Article  CAS  Google Scholar  * Ghanem, M. A. et al. _Nat. Rev. Mater_. https://doi.org/10.1038/s41578-020-00249-w (2020). * Anderson, L. & Boulatov, R. _Adv. Phys.

Org. Chem._ 52, 87–143 (2018). CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Chemistry, University of Liverpool, Crown Street,

Liverpool, UK Roman Boulatov Authors * Roman Boulatov View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Roman

Boulatov. ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Boulatov,

R. The liberating force of ultrasound. _Nat. Chem._ 13, 112–114 (2021). https://doi.org/10.1038/s41557-020-00623-9 Download citation * Published: 29 January 2021 * Issue Date: February 2021

* DOI: https://doi.org/10.1038/s41557-020-00623-9 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is

not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative