Relationship between human leukocyte antigen alleles and risk of kaposi’s sarcoma in cameroon

ABSTRACT Several studies published to date report associations between human leukocyte antigen (HLA) alleles and different types of Kaposi’s Sarcoma (KS). However, there is little

concordance between the HLA alleles identified and the populations studied. To test whether HLA alleles associate with KS in a Cameroonian case–control study, we performed high-resolution

HLA typing in KSHV seropositive individuals. Among HIV-positive individuals, carriers of _HLA-B*14:01_ were at a significantly higher risk of AIDS-KS (_p_ = 0.033). For HIV-negative

patients, a gene-wise comparison of allele frequencies identified the _HLA-B_ (_p_ = 0.008) and _-DQA1_ (_p_ = 0.002) loci as possible risk factors for endemic KS. Our study provides

additional understanding of genetic determinants of KS and their implications in disease pathogenesis. Further validation of these findings is needed to define the functional relevance of

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Am J Hum Genet. 2007;81:559–75. Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS We thank Randall Johnson, Frederick National Laboratory for Cancer Research (Frederick,

MD, USA), for providing guidance in the initial selection of study participants; the staff at SOCHIMIO and all study participants. This project has been funded in whole or in part with

federal funds from the Frederick National Laboratory for Cancer Research, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or

policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was

supported in part by the Intramural Research Program of the NIH, Frederick National Laboratory for Cancer Research, Center for Cancer Research. The original case–control study was funded in

part with federal funds from the National Cancer Institute, NIH under contract N01-CO-12400 and HHSN261200800001E and NIAID, NIH, under contract 1U01AI069927. AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, USA Elena M. Cornejo

Castro, Brian J. Morrison, Vickie A. Marshall, Nazzarena Labo, Wendell J. Miley, Nathan Clements & Denise Whitby * CCR Collaborative Bioinformatics Resource (CCBR), Center for Cancer

Research, NCI, Bethesda, MD, USA George Nelson * Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, USA George Nelson * SOCHIMO,

Yaoundé, Cameroon Paul Ndom & Mahamat Abassora * RTI International, Research Triangle Park, Triangle Park, NC, USA Kristen Stolka & Jennifer J. Hemingway-Foday * Basic Science

Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA Xiaojiang Gao & Mary Carrington * University of California San Diego, San Diego, CA, USA Jennifer S. Smith

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B.J., Marshall, V.A. _et al._ Relationship between human leukocyte antigen alleles and risk of Kaposi’s sarcoma in Cameroon. _Genes Immun_ 20, 684–689 (2019).

https://doi.org/10.1038/s41435-019-0077-9 Download citation * Received: 08 February 2019 * Revised: 24 April 2019 * Accepted: 28 April 2019 * Published: 20 May 2019 * Issue Date: November

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