
The significance of peri-transplantation minimal residual disease assessed by multiparameter flow cytometry on outcomes for adult aml patients receiving haploidentical allografts
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ABSTRACT A retrospective study (_n_ = 460) was performed to assess the relationship between minimal residual disease (MRD) and transplant outcomes in a haplo-stem cell transplantation (SCT)
setting. Patients from the pre-MRDneg group and the pre-MRDpos group had comparable outcomes. Compared to post-MRDneg patients, post-MRDpos patients had a higher incidence of relapse (100.0%
vs. 8.3%, _p_ < 0.001), lower incidences of overall survival (OS) (16.9% vs. 78.2%, _p_ < 0.001) and leukemia-free survival (LFS) (0% vs. 76.5%, _p_ < 0.001), and comparable
probability of NRM (13.4% vs. 16.9%, _p_ = 0.560). In a second set of analyses, all adult AML patients undergoing haplo-SCT were classified into the MRDneg/MRDneg group, the MRD decreasing
group, and the MRD increasing group according to MRD dynamics by flow cytometry peri-SCT. Compared to the other two groups, patients from the MRD increasing group had higher cumulative
incidences of relapse (MRD increasing, 100.0%; MRDneg/MRDneg, 9.6%; MRD decreasing, 19.2%; _p_ < 0.001) and worse probabilities of OS (MRD increasing, 28.5%; MRDneg/MRDneg, 76.3%; MRD
decreasing, 76.0%; p < 0.001) and LFS (MRD increasing, 0.0%; MRDneg/MRDneg, 73.9%; MRD decreasing, 74.0%; _p_ < 0.001). The results indicated that haploidentical allografts might have
a beneficial anti-leukemia effect in eradicating pretransplantation MRD, and MRD assessment peri-SCT is useful for risk stratification from a practical perspective. Access through your
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BEING VIEWED BY OTHERS MEASURABLE RESIDUAL DISEASE STATUS AND OUTCOME OF TRANSPLANT IN ACUTE MYELOID LEUKEMIA IN SECOND COMPLETE REMISSION: A STUDY BY THE ACUTE LEUKEMIA WORKING PARTY OF THE
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HLA-identical related donors. Biol Blood Marrow Transplant. 2017;24:627–32. Google Scholar Download references ACKNOWLEDGMENTS We thank all the faculty members that participated in these
studies. We would also like to thank American Journal Experts (www.aje.com) for the assistance in editing this manuscript. AUTHOR CONTRIBUTIONS Contribution: Y.-J.C. designed the study; J.
L, R. M, and Y.-J.C. collected data; J. L and Y.-J.C. analyzed the data and drafted the manuscript; all authors contributed to data interpretation, manuscript preparation, and approval of
the final version. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Peking University People’s Hospital & Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic
Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing, 100044, P.R. China Jing Liu, Rui Ma, Yan-Rong Liu, Lan-Ping Xu, Xiao-Hui Zhang, Huan Chen, Yu-Hong
Chen, Feng-Rong Wang, Wei Han, Yu-Qian Sun, Chen-Hua Yan, Fei-Fei Tang, Xiao-Dong Mo, Kai-Yan Liu, Qiao-Zhen Fan, Xiao-Jun Huang & Ying-Jun Chang * Peking-Tsinghua Center for Life
Sciences, Beijing, 100871, China Xiao-Jun Huang * Collaborative Innovation Center of Hematology, Peking University, Beijing, China Xiao-Jun Huang & Ying-Jun Chang Authors * Jing Liu View
author publications You can also search for this author inPubMed Google Scholar * Rui Ma View author publications You can also search for this author inPubMed Google Scholar * Yan-Rong Liu
View author publications You can also search for this author inPubMed Google Scholar * Lan-Ping Xu View author publications You can also search for this author inPubMed Google Scholar *
Xiao-Hui Zhang View author publications You can also search for this author inPubMed Google Scholar * Huan Chen View author publications You can also search for this author inPubMed Google
Scholar * Yu-Hong Chen View author publications You can also search for this author inPubMed Google Scholar * Feng-Rong Wang View author publications You can also search for this author
inPubMed Google Scholar * Wei Han View author publications You can also search for this author inPubMed Google Scholar * Yu-Qian Sun View author publications You can also search for this
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AUTHOR Correspondence to Ying-Jun Chang. ETHICS DECLARATIONS CONFLICT OF INTEREST The authors declare that they have no conflict of interest. ELECTRONIC SUPPLEMENTARY MATERIAL SUPPLEMENT
TABLE 1 RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Liu, J., Ma, R., Liu, YR. _et al._ The significance of peri-transplantation minimal residual
disease assessed by multiparameter flow cytometry on outcomes for adult AML patients receiving haploidentical allografts. _Bone Marrow Transplant_ 54, 567–577 (2019).
https://doi.org/10.1038/s41409-018-0300-8 Download citation * Received: 07 February 2018 * Revised: 27 June 2018 * Accepted: 12 July 2018 * Published: 20 August 2018 * Issue Date: April 2019
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