The significance of peri-transplantation minimal residual disease assessed by multiparameter flow cytometry on outcomes for adult aml patients receiving haploidentical allografts

ABSTRACT A retrospective study (_n_ = 460) was performed to assess the relationship between minimal residual disease (MRD) and transplant outcomes in a haplo-stem cell transplantation (SCT)

setting. Patients from the pre-MRDneg group and the pre-MRDpos group had comparable outcomes. Compared to post-MRDneg patients, post-MRDpos patients had a higher incidence of relapse (100.0%

vs. 8.3%, _p_ < 0.001), lower incidences of overall survival (OS) (16.9% vs. 78.2%, _p_ < 0.001) and leukemia-free survival (LFS) (0% vs. 76.5%, _p_ < 0.001), and comparable

probability of NRM (13.4% vs. 16.9%, _p_ = 0.560). In a second set of analyses, all adult AML patients undergoing haplo-SCT were classified into the MRDneg/MRDneg group, the MRD decreasing

group, and the MRD increasing group according to MRD dynamics by flow cytometry peri-SCT. Compared to the other two groups, patients from the MRD increasing group had higher cumulative

incidences of relapse (MRD increasing, 100.0%; MRDneg/MRDneg, 9.6%; MRD decreasing, 19.2%; _p_ < 0.001) and worse probabilities of OS (MRD increasing, 28.5%; MRDneg/MRDneg, 76.3%; MRD

decreasing, 76.0%; p < 0.001) and LFS (MRD increasing, 0.0%; MRDneg/MRDneg, 73.9%; MRD decreasing, 74.0%; _p_ < 0.001). The results indicated that haploidentical allografts might have

a beneficial anti-leukemia effect in eradicating pretransplantation MRD, and MRD assessment peri-SCT is useful for risk stratification from a practical perspective. Access through your

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BEING VIEWED BY OTHERS MEASURABLE RESIDUAL DISEASE STATUS AND OUTCOME OF TRANSPLANT IN ACUTE MYELOID LEUKEMIA IN SECOND COMPLETE REMISSION: A STUDY BY THE ACUTE LEUKEMIA WORKING PARTY OF THE

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HLA-identical related donors. Biol Blood Marrow Transplant. 2017;24:627–32. Google Scholar  Download references ACKNOWLEDGMENTS We thank all the faculty members that participated in these

studies. We would also like to thank American Journal Experts (www.aje.com) for the assistance in editing this manuscript. AUTHOR CONTRIBUTIONS Contribution: Y.-J.C. designed the study; J.

L, R. M, and Y.-J.C. collected data; J. L and Y.-J.C. analyzed the data and drafted the manuscript; all authors contributed to data interpretation, manuscript preparation, and approval of

the final version. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Peking University People’s Hospital & Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic

Stem Cell Transplantation, No. 11 South Street of Xizhimen, Xicheng District, Beijing, 100044, P.R. China Jing Liu, Rui Ma, Yan-Rong Liu, Lan-Ping Xu, Xiao-Hui Zhang, Huan Chen, Yu-Hong

Chen, Feng-Rong Wang, Wei Han, Yu-Qian Sun, Chen-Hua Yan, Fei-Fei Tang, Xiao-Dong Mo, Kai-Yan Liu, Qiao-Zhen Fan, Xiao-Jun Huang & Ying-Jun Chang * Peking-Tsinghua Center for Life

Sciences, Beijing, 100871, China Xiao-Jun Huang * Collaborative Innovation Center of Hematology, Peking University, Beijing, China Xiao-Jun Huang & Ying-Jun Chang Authors * Jing Liu View

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TABLE 1 RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Liu, J., Ma, R., Liu, YR. _et al._ The significance of peri-transplantation minimal residual

disease assessed by multiparameter flow cytometry on outcomes for adult AML patients receiving haploidentical allografts. _Bone Marrow Transplant_ 54, 567–577 (2019).

https://doi.org/10.1038/s41409-018-0300-8 Download citation * Received: 07 February 2018 * Revised: 27 June 2018 * Accepted: 12 July 2018 * Published: 20 August 2018 * Issue Date: April 2019

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