Fatty acid diet and prostate cancer: a treasure hunt or a wild goose chase?

While there are several factors that contribute to cancer development, mounting evidence suggests that dietary lipids may play an important role. The idea that what we eat could impact

cancer risk has gained attention in recent years, and the lipid-diet-cancer connection has emerged as a promising research field. In fact, there has been an increasing widespread acceptance

of the role played by lipid metabolism in tumor growth, despite its long-standing underestimation. Cancer cells have the ability to acquire, synthesize, and accumulate fatty acids in the

form of lipid droplets [1]. These fatty acids are known to contribute significantly to cancer cell survival in the acidic and hypoxic tumor microenvironment, and they also promote cell

proliferation and invasiveness [1].

Prostate cancer (PCa) is not an exception, and should not be overlooked. In the contemporary urologic oncology research, there is an increased focus on gaining a thorough understanding of

the changes in lipid metabolism in PCa, the regulatory mechanisms responsible for these alterations, and their significance in both development and progression of the disease, and this in

order to develop potential therapeutic strategies [2,3,4].

Conceptualization: GM, TR, KK, KZ. Writing – first draft: GM. Writing – review and editing: GM, TR, KK, PVA, KZ. Supervision: TR, KZ.

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