A family of NICU graduates! | Pediatric Research

A family of NICU graduates! | Pediatric Research


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You have full access to this article via your institution. Download PDF My parents, an engineer and a physician, inspired me to pursue science and medicine while growing up in Chennai,


India. Witnessing umpteen number of cases with birth asphyxia and consequent long-term neurological complications during my training left an everlasting impression on me. These cases


influenced my decision to pursue a career in academic pediatrics and, subsequently, neonatology. I have been fortunate to work with several exceptional mentors, beginning with Dr. Kusum


Viswanathan, at Brookdale Hospital in New York, where I completed my pediatric residency. From clinical pediatrics to basic statistics, she instilled in me an understanding of the core


concepts of research. During my residency, I met my wife, Munmun, a constant source of inspiration, and a neonatologist. Together we worked with Dr. Roger Kim on quality improvement projects


and collaborated in a multicenter non-invasive ventilation trial.1 The turning point in my career was meeting Dr. Satyan Lakshminrusimha, a pioneer in translational research and my role


model. During my neonatology fellowship at the University at Buffalo (UB), under his guidance, I worked on both basic science and clinical


research.2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21 Our lab, complete with a team of experienced personnel, is one of the handful centers in the US conducting perinatal


translational research. My greatest motivation was the birth of my son, Ishaan. He was born premature and has benefitted from every aspect of neonatal and pediatric research, which further


inspires me to conduct research addressing prematurity and its problems. Currently, my work focuses on studying the effects of gas exchange on pulmonary and systemic hemodynamics in both


preterm and term models during and post-resuscitation. My recently published research, investigated the impact of oxygen used during preterm resuscitation, an area that continues to be


controversial.7 This research earned me a young investigator award at the Eastern Society of Pediatric Research. As a junior faculty at UB, I have evaluated the effect of placental


transfusion during preterm resuscitation (supported by Buswell, UBMD & Kaleida Health).11 Also, I am assessing ways to improve the efficiency of neonatal resuscitation, a project funded


by AAP NRP. With a bioinformatics background, I am fortunate to be part of the neonatal research network alongside Dr. Anne Marie Reynolds. Moving forward, I intend to explore the combined


impact of oxygen use and placental transfusion during preterm resuscitation. I urge young researchers to find supportive mentors and colleagues. I would not be where I am today without them.


REFERENCES * Kirpalani, H. et al. A trial comparing noninvasive ventilation strategies in preterm infants. _N. Engl. J. Med._ 369, 611–620 (2013). Article  CAS  Google Scholar  *


Chandrasekharan, P., Konduri, G., Basir, M., Klein, J. & Lakshminrusimha, S. Risk stratification for congenital diaphragmatic hernia-is it all oxygenation but not ventilation? _J.


Perinatol._ 38, 608–609 (2018). Article  Google Scholar  * Chandrasekharan, P. et al. Early use of inhaled nitric oxide in preterm infants: is there a rationale for selective approach? _Am.


J. Perinatol._ 34, 428–440 (2017). Google Scholar  * Chandrasekharan, P. & Lakshminrusimha, S. The effectiveness of oral dextrose gel for the treatment of neonatal hypoglycaemia remains


unclear. _Evid. Based. Nurs._ 20, 80–81 (2017). Article  Google Scholar  * Chandrasekharan, P. & Lakshminrusimha, S. Single dose of prophylactic oral dextrose gel reduces neonatal


hypoglycaemia. _Evid. Based. Med._ 22, 62 (2017). Article  Google Scholar  * Chandrasekharan, P., Nrusimha, A., Rawat, M., Lakshminrusimha, S. Using paralytic as part of premedication for


elective intubation of premature neonates may result in transient impairment of ventilation. _Am. J. Perinatol_. (2018) * Chandrasekharan, P., et al. Effect of various inspired oxygen


concentrations on pulmonary and systemic hemodynamics and oxygenation during resuscitation in a transitioning preterm model. _Pediatr. Res_. (2018) * Chandrasekharan, P., Rawat, M. &


Lakshminrusimha, S. Complications of prematurity: an infographic. _J. Perinatol._ 37, 1185–1186 (2017). Article  CAS  Google Scholar  * Chandrasekharan, P., Rawat, M., Reynolds, A. M.,


Phillips, K. & Lakshminrusimha, S. Apnea, bradycardia and desaturation spells in premature infants: impact of a protocol for the duration of 'spell-free' observation on


interprovider variability and readmission rates. _J. Perinatol._ 38, 86–91 (2018). Article  CAS  Google Scholar  * Chandrasekharan, P. et al. Continuous capnography monitoring during


resuscitation in a transitional large mammalian model of asphyxial cardiac arrest. _Pediatr. Res._ 81, 898–904 (2017). Article  Google Scholar  * Chandrasekharan, P., et al. Placental


transfusion during resuscitation of a partially asphyxiated preterm model. _Pediatr. Acad. Soc. Meet_. 1725.8. (2018) * Chandrasekharan, P. K., Rawat, M., Madappa, R., Rothstein, D. H. &


Lakshminrusimha, S. Congenital diaphragmatic hernia – a review. _Matern. Health Neonatol. Perinatol._ 3, 6 (2017). Article  Google Scholar  * Chandrasekharan, P. K. et al. Continuous


end-tidal carbon dioxide monitoring during resuscitation of asphyxiated term lambs. _Neonatology._ 109, 265–273 (2016). Article  CAS  Google Scholar  * Rawat, M., et al. Oral dextrose gel


reduces the need for intravenous dextrose therapy in neonatal hypoglycemia. _Biomed. Hub_ 1, pii: 448511 (2016). * Rawat, M. et al. Neonatal resuscitation adhering to oxygen saturation


guidelines in asphyxiated lambs with meconium aspiration. _Pediatr. Res._ 79, 583–588 (2016). Article  CAS  Google Scholar  * Rawat, M. et al. Oxygen saturation index and severity of hypoxic


respiratory failure. _Neonatology._ 107, 161–166 (2015). Article  CAS  Google Scholar  * Rawat, M., Nangia, S., Chandrasekharan, P. & Lakshminrusimha, S. Approach to infants born


through meconium stained amniotic fluid: evolution based on evidence? _Am. J. Perinatol._ 35, 815–822 (2018). Article  Google Scholar  * Singh, A. P., Balluz, R. & Chandrasekharan, P.


Poor oral intake in a late preterm twin - usual symptom with an unusual diagnosis. _Heart Lung_ 47, 162–165 (2018). Article  CAS  Google Scholar  * Vali, P., et al. Evaluation of timing and


route of epinephrine in a neonatal model of asphyxial arrest. J. Am. Heart Assoc. 6, pii: e004402 (2017). * Vali, P. et al. Continuous chest compressions during sustained inflations in a


perinatal asphyxial cardiac arrest lamb model. _Pediatr. Crit. Care. Med._ 18, e370–e377 (2017). Article  Google Scholar  * Vali, P. et al. Hemodynamics and gas exchange during chest


compressions in neonatal resuscitation. _PLoS ONE_ 12, e0176478 (2017). Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Neonatology,


Department of Pediatrics, Oishei Children’s Hospital, University at Buffalo, Buffalo, NY, 14203, USA Praveen Chandrasekharan Authors * Praveen Chandrasekharan View author publications You


can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Praveen Chandrasekharan. ADDITIONAL INFORMATION PUBLISHER'S NOTE: Springer Nature remains


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Chandrasekharan, P. A family of NICU graduates!. _Pediatr Res_ 84, 578–579 (2018). https://doi.org/10.1038/s41390-018-0157-y Download citation * Received: 31 July 2018 * Accepted: 01 August


2018 * Published: 24 August 2018 * Issue Date: November 2018 * DOI: https://doi.org/10.1038/s41390-018-0157-y SHARE THIS ARTICLE Anyone you share the following link with will be able to read


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