The consortium on vulnerability to externalizing disorders and addictions (c-veda): an accelerated longitudinal cohort of children and adolescents in india

ABSTRACT The global burden of disease attributable to externalizing disorders such as alcohol misuse calls urgently for effective prevention and intervention. As our current knowledge is

mainly derived from high-income countries such in Europe and North-America, it is difficult to address the wider socio-cultural, psychosocial context, and genetic factors in which risk and

resilience are embedded in low- and medium-income countries. c-VEDA was established as the first and largest India-based multi-site cohort investigating the vulnerabilities for the

development of externalizing disorders, addictions, and other mental health problems. Using a harmonised data collection plan coordinated with multiple cohorts in China, USA, and Europe,

baseline data were collected from seven study sites between November 2016 and May 2019. Nine thousand and ten participants between the ages of 6 and 23 were assessed during this time,

amongst which 1278 participants underwent more intensive assessments including MRI scans. Both waves of follow-ups have started according to the accelerated cohort structure with planned

missingness design. Here, we present descriptive statistics on several key domains of assessments, and the full baseline dataset will be made accessible for researchers outside the

consortium in September 2019. More details can be found on our website [cveda.org]. Access through your institution Buy or subscribe This is a preview of subscription content, access via

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS CHILD MALTREATMENT AS A TRANSDIAGNOSTIC RISK FACTOR FOR THE

EXTERNALIZING DIMENSION: A MENDELIAN RANDOMIZATION STUDY Article Open access 22 August 2024 CLINICAL, ENVIRONMENTAL, AND GENETIC RISK FACTORS FOR SUBSTANCE USE DISORDERS: CHARACTERIZING

COMBINED EFFECTS ACROSS MULTIPLE COHORTS Article 04 October 2022 PARSING GENETICALLY INFLUENCED RISK PATHWAYS: GENETIC LOCI IMPACT PROBLEMATIC ALCOHOL USE VIA EXTERNALIZING AND SPECIFIC RISK

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Google Scholar  Download references FUNDING c-VEDA is jointly funded by the Indian Council for Medical Research (ICMR/MRC/3/M/2015-NCD-I) and the Newton Grant from the Medical Research

Council (MR/N000390/1), United Kingdom. THE C-VEDA CONSORTIUM Vivek Benegal29, Gunter Schumann30, Pratima Murthy31, Bharath Holla31, Eesha Sharma32, Meera Purushottam33, Rose Dawn Bharath34,

Sanjeev Jain31, Mathew Varghese31, Thennarasu Kandavel35, Deepak Jayarajan31, Keshav Kumar36, Preeti Jacob32, Amit Chakrabarti37, Rajkumar Lenin Singh38, Roshan Lourembam Singh38, Debasish

Basu39, Subodh Bhagyalakshmi Nanjayya39, Chirag Kumar Ahuja40, Kartik Kalyanram41, Kamakshi Kartik41, Kumaran Kalyanram42, Krishnaveni Ghattu42, Murali Krishna43, Rebecca Kuriyan44, Sunita

Simon Kurpad45, Sylvane Desrivieres30, Gareth Barker46, Udita Iyengar30, Yuning Zhang30, Nilakshi Vaidya30, Matthew Hickman47, Jon Heron48, Gwen Fernandes49, Mireille Toledano50, Dimitri

Papadopoulos Orfanos51, Madhavi Rangaswamy52, Gitanjali Narayanan53, Urvakhsh Meherwan Mehta31, Paul Elliott50, Satish Chandra Girimaji32, Madhu Khullar54, Niranjan Khandelwal55, Nainesh

Joshi54, Amit55, Debangana Bhattacharya56, Bidisha Haque56, Arpita Ghosh56, Alisha Nagraj56, Anirban Basu56, Mriganka Mouli Pandit56, Subhadip Das56, Anupa Yadav56, Surajit Das56, Sanjit

Roy56, Pawan Kumar Maurya56, Ningthoujam Debala Chanu38, Fujica M C38, Victoria Ph.38, Celina Phurailatpam38, Amritha Gourisankar41, Geetha Rani41, Sujatha B41, Caroline Fall57, Kiran K N42,

Ramya M C42, Chaithra Urs42, Santhosh N42, Somashekhara R42, Divyashree K42, Arathi Rao44, Poornima R44, Saswathika Tripathy29, Neha Parashar29, Dhanalakshmi D29, Nayana K B29, Ashwini

Kalkunte Seshadri29, Sathish Kumar29, Thamodaran Arumugam29, Apoorva Safai29, Suneela Kuman Baligar29, Anthony Mary Cyril29, Aanchal Sharda29, Rashmitha29, Ashika Anne Roy29, Shivamma D29,

Kiran L29, Bhavana B R29 AUTHOR INFORMATION Author notes * These authors contributed equally: Yuning Zhang, Nilakshi Vaidya, Vivek Benegal, Gunter Schumann * The c-VEDA consortium

(www.cveda.org) authors and affiliations are listed in the Supplementary Materials AUTHORS AND AFFILIATIONS * Centre for Population Neuroscience and Precision Medicine (PONS), MRC Social,

Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK Yuning Zhang, Nilakshi Vaidya, Udita Iyengar, 

Sylvane Desrivieres & Gunter Schumann * Centre for Innovation in Mental Health, School of Psychology, University of Southampton, Southampton, UK Yuning Zhang * Centre for Addiction

Medicine, National Institute of Mental Health and Neurosciences, Bengaluru, India Nilakshi Vaidya, Pratima Murthy & Vivek Benegal * Department of Child & Adolescent Psychiatry,

National Institute of Mental Health and Neurosciences, Bengaluru, India Eesha Sharma & Preeti Jacob * Department of Psychiatry, National Institute of Mental Health and Neurosciences,

Bengaluru, India Bharath Holla, Sanjeev Jain, Deepak Jayarajan, Pratima Murthy & Mathew Varghese * Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education

& Research, Chandigarh, India Chirag K. Ahuja * Department of Neuroimaging, Institute of Psychology, Psychiatry & Neuroscience, London, King’s College, London, UK Gareth J. Barker *

Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India Debasish Basu & B. N. Subodh * Department of Neuroimaging and Interventional

Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, India Rose Dawn Bharath * ICMR-Regional Occupational Health Centre, Kolkata, India Amit Chakrabarti * MRC Centre

for Environment and Health, School of Public Health, Imperial College London, London, UK Paul Elliott & Mireille Toledano * Population Health Sciences, Bristol Medical School, University

of Bristol, Bristol, UK Gwen Fernandes * Rishi Valley Rural Health Centre, Rishi Valley, India Amritha Gourisankar, Kartik Kalyanram & Kamakshi Kartik * Centre for Public Health,

Bristol Medical School, University of Bristol, Bristol, UK Jon Heron * Bristol Medical School, University of Bristol, Bristol, UK Matthew Hickman * Foundation for Research and Advocacy in

Mental Health, Mysuru, India Murali Krishna * Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysuru, India Ghattu Krishnaveni & Kalyanaraman Kumaran * Department of Mental

Health and Clinical Psychology, National Institute of Mental Health and Neurosciences, Bengaluru, India Keshav Kumar * MRC Lifecourse Epidemiology Unit, University of Southampton,

Southampton, UK Kalyanaraman Kumaran * Division of Nutrition, St John’s Research Institute, Bengaluru, India Rebecca Kuriyan * NeuroSpin, CEA, Université Paris-Saclay, Paris, France Dimitri

P. Orfanos * Molecular Genetics Laboratory, National Institute of Mental Health and Neurosciences, Bengaluru, India Meera Purushottam * Department of Psychology, CHRIST (deemed to be

university), Bengaluru, India Madhavi Rangaswamy * Department of Psychiatry & Department of Medical Ethics, St. John’s Medical College & Hospital, Bengaluru, India Sunita Simon

Kupard * Department of Psychiatry, Regional Institute of Medical Sciences, Imphal, Manipur, India Lenin Singh & Roshan Singh * Department of Biostatistics, National Institute of Mental

Health and Neurosciences, Bengaluru, India Kandavel Thennarasu * Population Neuroscience and Precision Medicine (PONS), LIN-Charite Research Group Department of Psychiatry and Psychotherapy,

Charite, CCM, Humboldt University, Berlin, Germany Gunter Schumann * Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, PR China Gunter

Schumann * Centre for Addiction Medicine, National Institute of Mental Health and Neurosciences, Bangalore, India Vivek Benegal, Saswathika Tripathy, Neha Parashar, Dhanalakshmi D, Nayana K

B, Ashwini Kalkunte Seshadri, Sathish Kumar, Thamodaran Arumugam, Apoorva Safai, Suneela Kuman Baligar, Anthony Mary Cyril, Aanchal Sharda,  Rashmitha, Ashika Anne Roy, Shivamma D, Kiran L 

& Bhavana B R * Centre for Population Neuroscience and Precision Medicine, MRC Social, Genetic, Developmental Psychiatry Centre, Institute of Psychology, Psychiatry & Neuroscience,

King’s College London, London, UK Gunter Schumann, Sylvane Desrivieres, Udita Iyengar, Yuning Zhang & Nilakshi Vaidya * Department of Psychiatry, National Institute of Mental Health and

Neurosciences, Bangalore, India Pratima Murthy, Bharath Holla, Sanjeev Jain, Mathew Varghese, Deepak Jayarajan & Urvakhsh Meherwan Mehta * Department of Child & Adolescent

Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India Eesha Sharma, Preeti Jacob & Satish Chandra Girimaji * Molecular Genetics Laboratory, National

Institute of Mental Health and Neurosciences, Bangalore, India Meera Purushottam * Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and

Neurosciences, Bangalore, India Rose Dawn Bharath * Department of Biostatistics, National Institute of Mental Health and Neurosciences, Bangalore, India Thennarasu Kandavel * Department of

Mental Health and Clinical Psychology, National Institute of Mental Health and Neurosciences, Bangalore, India Keshav Kumar * ICMR-Regional Occupational Health Centre, Kolkata, India Amit

Chakrabarti * Regional Institute of Medical Sciences, Imphal, Manipur, India Rajkumar Lenin Singh, Roshan Lourembam Singh, Ningthoujam Debala Chanu, Fujica M C, Victoria Ph. & Celina

Phurailatpam * Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India Debasish Basu & Subodh Bhagyalakshmi Nanjayya * Department of

Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education & Research, Chandigarh, India Chirag Kumar Ahuja * Rishi Valley, Rural Health Centre, Madanapalle, Andhra Pradesh,

India Kartik Kalyanram, Kamakshi Kartik, Amritha Gourisankar, Geetha Rani & Sujatha B * Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, India Kumaran Kalyanram, 

Krishnaveni Ghattu, Kiran K N, Ramya M C, Chaithra Urs, Santhosh N, Somashekhara R & Divyashree K * Foundation for Research and Advocacy in Mental Health, Mysore, India Murali Krishna *

Division of Nutrition, St John’s Research Institute, Bangalore, India Rebecca Kuriyan, Arathi Rao & Poornima R * Department of Psychiatry & Department of Medical Ethics, St. John’s

Medical College & Hospital, Bangalore, India Sunita Simon Kurpad * Department of Neuroimaging, Institute of Psychology, Psychiatry & Neuroscience, King’s College London, London, UK

Gareth Barker * Bristol Medical School, University of Bristol, Bristol, UK Matthew Hickman * Centre for Public Health, Bristol Medical School, University of Bristol, Bristol, UK Jon Heron *

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK Gwen Fernandes * MRC Centre for Environment and Health, School of Public Health, Imperial College

London, London, UK Mireille Toledano & Paul Elliott * NeuroSpin, CEA, Université Paris-Saclay, Paris, France Dimitri Papadopoulos Orfanos * Department of Psychology, Christ University,

Bangalore, India Madhavi Rangaswamy * Department of Clinical Psychology, National Institute of Mental Health and Neurosciences, Bangalore, India Gitanjali Narayanan * Department of

Experimental Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India Madhu Khullar & Nainesh Joshi * Department of Radiodiagnosis and Imaging, Post

Graduate Institute of Medical Education and Research, Chandigarh, India Niranjan Khandelwal &  Amit * ICMR-Regional Occupational Health Centre, Eastern, Kolkata, India Debangana

Bhattacharya, Bidisha Haque, Arpita Ghosh, Alisha Nagraj, Anirban Basu, Mriganka Mouli Pandit, Subhadip Das, Anupa Yadav, Surajit Das, Sanjit Roy & Pawan Kumar Maurya * MRC Lifecourse

Epidemiology Unit, University of Southamtpon, Southamtpon, UK Caroline Fall Authors * Yuning Zhang View author publications You can also search for this author inPubMed Google Scholar *

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CONSORTIUM * Vivek Benegal * , Gunter Schumann * , Pratima Murthy * , Bharath Holla * , Eesha Sharma * , Meera Purushottam * , Rose Dawn Bharath * , Sanjeev Jain * , Mathew Varghese * , 

Thennarasu Kandavel * , Deepak Jayarajan * , Keshav Kumar * , Preeti Jacob * , Amit Chakrabarti * , Rajkumar Lenin Singh * , Roshan Lourembam Singh * , Debasish Basu * , Subodh Bhagyalakshmi

Nanjayya * , Chirag Kumar Ahuja * , Kartik Kalyanram * , Kamakshi Kartik * , Kumaran Kalyanram * , Krishnaveni Ghattu * , Murali Krishna * , Rebecca Kuriyan * , Sunita Simon Kurpad * , 

Sylvane Desrivieres * , Gareth Barker * , Udita Iyengar * , Yuning Zhang * , Nilakshi Vaidya * , Matthew Hickman * , Jon Heron * , Gwen Fernandes * , Mireille Toledano * , Dimitri

Papadopoulos Orfanos * , Madhavi Rangaswamy * , Gitanjali Narayanan * , Urvakhsh Meherwan Mehta * , Paul Elliott * , Satish Chandra Girimaji * , Madhu Khullar * , Niranjan Khandelwal * , 

Nainesh Joshi * ,  Amit * , Debangana Bhattacharya * , Bidisha Haque * , Arpita Ghosh * , Alisha Nagraj * , Anirban Basu * , Mriganka Mouli Pandit * , Subhadip Das * , Anupa Yadav * , 

Surajit Das * , Sanjit Roy * , Pawan Kumar Maurya * , Ningthoujam Debala Chanu * , Fujica M C * , Victoria Ph. * , Celina Phurailatpam * , Amritha Gourisankar * , Geetha Rani * , Sujatha B *

, Caroline Fall * , Kiran K N * , Ramya M C * , Chaithra Urs * , Santhosh N * , Somashekhara R * , Divyashree K * , Arathi Rao * , Poornima R * , Saswathika Tripathy * , Neha Parashar * , 

Dhanalakshmi D * , Nayana K B * , Ashwini Kalkunte Seshadri * , Sathish Kumar * , Thamodaran Arumugam * , Apoorva Safai * , Suneela Kuman Baligar * , Anthony Mary Cyril * , Aanchal Sharda *

,  Rashmitha * , Ashika Anne Roy * , Shivamma D * , Kiran L *  & Bhavana B R CORRESPONDING AUTHORS Correspondence to Vivek Benegal or Gunter Schumann. ETHICS DECLARATIONS CONFLICT OF

INTEREST The authors declare that they have no conflict of interest. ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in published

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ARTICLE Zhang, Y., Vaidya, N., Iyengar, U. _et al._ The Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA): an accelerated longitudinal cohort of children and

adolescents in India. _Mol Psychiatry_ 25, 1618–1630 (2020). https://doi.org/10.1038/s41380-020-0656-1 Download citation * Received: 01 July 2019 * Revised: 06 January 2020 * Accepted: 17

January 2020 * Published: 12 March 2020 * Issue Date: August 2020 * DOI: https://doi.org/10.1038/s41380-020-0656-1 SHARE THIS ARTICLE Anyone you share the following link with will be able to

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