Effect of patient gender on short-term blood pressure variability in hemodialysis patients

ABSTRACT Increased blood pressure variability (BPV) is strongly associated with cardiovascular events in end-stage kidney disease patients. Male hemodialysis patients present higher

cardiovascular risk compared with females. The aim of this study is to investigate sex differences in short-term BPV in hemodialysis patients. 129 male and 91 female hemodialysis patients

that underwent 48-h ABPM were included in this analysis. Standard deviation (SD), weighted SD (wSD), coefficient of variation (CV), and average real variability (ARV) of SBP and DBP were

calculated with validated formulas. Age, dialysis vintage and history of major comorbidities did not differ between men and women. 48-h SBP/DBP (137.2 ± 17.4/81.9 ± 12.1 mmHg vs 132.2 ± 

19.2/75.9 ± 11.7 mmHg, _p_ = 0.045/<0.001) was significantly higher in men than women. During the 48-h period, all systolic BPV indices were similar between men and women (48-h SBP-ARV:

12.0 ± 2.9 vs 12.1 ± 3.2 mmHg, _p_ = 0.683); 48-h DBP-SD, DBP-wSD and DBP-ARV (9.1 ± 1.6 vs 8.4 ± 1.8 mmHg, _p_ = 0.005) were higher in men. In conclusion, short-term diastolic BPV indices

are higher in male than female hemodialysis patients. Increased BPV may impact on the higher incidence of cardiovascular events observed in male hemodialysis patients. Access through your

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SIMILAR CONTENT BEING VIEWED BY OTHERS BLOOD PRESSURE VARIABILITY IN CKD PATIENTS WITH AND WITHOUT NOCTURNAL HYPERTENSION Article 28 February 2025 ACCURACY OF 24 H AMBULATORY BLOOD PRESSURE

RECORDINGS FOR DIAGNOSING HIGH 44 H BLOOD PRESSURE IN HEMODIALYSIS: A DIAGNOSTIC TEST STUDY Article 30 January 2024 CHANGES IN PRE-DIALYSIS BLOOD PRESSURE VARIABILITY IN THE FIRST YEAR OF

DIALYSIS ASSOCIATE WITH MORTALITY IN EUROPEAN HEMODIALYSIS PATIENTS: A RETROSPECTIVE COHORT STUDY ON BEHALF OF THE MONDO INITIATIVE Article 09 June 2020 DATA AVAILABILITY The datasets

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AFFILIATIONS * Department of Nephrology, Hippokration Hospital, Aristotle University, Thessaloniki, Greece Marieta P. Theodorakopoulou, Maria-Eleni Alexandrou, Artemios G. Karagiannidis, 

Virginia Geladari, Georgia Polychronidou, Aikaterini Papagianni & Pantelis Sarafidis Authors * Marieta P. Theodorakopoulou View author publications You can also search for this author

inPubMed Google Scholar * Maria-Eleni Alexandrou View author publications You can also search for this author inPubMed Google Scholar * Artemios G. Karagiannidis View author publications You

can also search for this author inPubMed Google Scholar * Virginia Geladari View author publications You can also search for this author inPubMed Google Scholar * Georgia Polychronidou View

author publications You can also search for this author inPubMed Google Scholar * Aikaterini Papagianni View author publications You can also search for this author inPubMed Google Scholar

* Pantelis Sarafidis View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS Research idea and study design: MT, PS; data acquisition: AK, VG, GP;

statistical analysis: MT, MA; data analysis and interpretation: MT, MA, PS; manuscript drafting: MT, PS; supervision/mentorship: AP, PS. CORRESPONDING AUTHOR Correspondence to Pantelis

Sarafidis. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. ETHICAL APPROVAL The study protocol was approved by the Ethics Committee of School of Medicine,

Aristotle University of Thessaloniki and all evaluations were performed according to the Declaration of Helsinki (2013 Amendment). ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature

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Theodorakopoulou, M.P., Alexandrou, ME., Karagiannidis, A.G. _et al._ Effect of patient gender on short-term blood pressure variability in hemodialysis patients. _J Hum Hypertens_ 37,

519–523 (2023). https://doi.org/10.1038/s41371-022-00725-6 Download citation * Received: 28 March 2022 * Revised: 23 June 2022 * Accepted: 05 July 2022 * Published: 16 July 2022 * Issue

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