644 Doppler-Derived Diastolic Ventricular Function in Infants with Birth Weight Less Than 1250 G During First 48 Hours of Life

Background and aims: To assess diastolic function in preterm infants less than 1250 g during first 48 hours of life and correlate with clinical parameters and cardiac output measurements.

Methods: A prospective observational studyNewborns with birth weight < 1250g were eligible for enrolment Newborns with congenital heart disease (excluding patent ductus arteriosus) or major

congenital malformations were excludedDoppler-derived parameters (early and atrial filling time velocity integral, early filling acceleration time, atrial filling fraction and isovolumic

relaxation time) were measured on tricuspid and mitral valves at 6, 12, 24 and 48 hours of age Ductal patency and flow was also assessed and superior vena cava flow was measured.

Results: 10 neonates were enrolled following parental consent The mean birth weight was 767 g (SD±184), mean gestational age was 253 weeks (SD±14) The mean tricuspid valve isovolumic

relaxation time (TV IVRT) at 6 hrs of age was 76 ms, at 12 hours 74 ms, at 24 hours 60 ms and at 48 hours 60 ms The mean mitral valve isovolumic relaxation time (MV IVRT) at 6 hrs of age was

58 ms, at 12 hours 57 ms, at 24 hours 47 ms and at 48 hours 52 ms There was a statistically significant negative correlation between MV IVRT and superior vena cava flow (SVC) (r= -045,

p=0004).

Conclusion: This is the first description of Dopplerderived diastolic ventricular function parameters in extremely preterm infants during first 48 hours of life.

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