Intellectual and psychological performance in males born small for gestational age with and without catch-up growth

Intellectual and psychological performance in males born small for gestational age with and without catch-up growth


Play all audios:

Loading...

ABSTRACT Infants born small for gestational age (SGA) have an increased risk of neurologic and intellectual dysfunction. Most of these infants catch up in growth and attain normal height,


although some do not. Whether catch-up growth influences intellectual function is not known. To analyze whether intellectual and psychological performance of males in early adulthood are


associated with body size at birth or by catch-up growth in height among boys, a population-based cohort was studied. This cohort included all male singletons born without congenital


malformations in Sweden from 1973 to 1978 and alive at 18 y (_n_ = 276,033). Information from the Swedish Birth Register was individually linked to the Swedish Conscript Register. Of 254,426


conscripted males, information on intellectual and psychological performance was available for 97% and 91%, respectively. Low birth weight, short birth length, small head circumference at


birth, and preterm birth increased the risk of subnormal intellectual and psychological performance. Among SGA-born males, the most important predictor was the absence of catch-up growth.


Being born SGA is associated with increased risk of subnormal intellectual and psychological performance. The data strongly support the view that, for males born SGA, it is an advantage to


have catch-up growth in length. SIMILAR CONTENT BEING VIEWED BY OTHERS BIRTH SIZE, SCHOOL PERFORMANCE AND FAMILY SOCIAL POSITION: A STUDY OF 650,000 CHILDREN Article Open access 29 July 2023


VISUOSPATIAL WORKING MEMORY OF CHILDREN AND ADULTS BORN VERY PRETERM AND/OR VERY LOW BIRTH WEIGHT Article 18 December 2021 VISUOSPATIAL OUTCOMES OF A PROSPECTIVE NATIONAL COHORT OF YOUNG


ADULTS WITH VERY LOW BIRTHWEIGHT Article Open access 07 February 2025 MAIN Several studies indicate that infants born SGA have a higher risk of minimal neurologic dysfunction later in life,


reduced mental development potential, and increased risk of subnormal intellectual and psychological performance compared with infants born appropriate for gestational age (1–9). In these


studies, SGA was defined based on low birth weight for gestational age. Growth in children and height in adults are often used as indicators of nutrition and well being (10–12). A positive


correlation between height and intelligence has generally been reported (13, 14). In a study of young Danish men, intelligence test scores were above the mean among tall men but below in


short men (15). We have recently demonstrated that apparently healthy short young men had lower intellectual performance compared with taller men, and that the mean intelligence test score


generally increased with height (16). Infants born short for gestational age have an increased risk of short adult stature (17–19). Data from Barker's group indicate that being small at


birth is a threat to cardiovascular health, especially if obese in adulthood. The question has therefore been raised if catch-up growth in SGA children is a risk rather than an advantage


(20). Lack of linear catch-up growth, however, could be a sign of severe growth restriction and brain affections. The aim of this study was to analyze whether body size at birth among males


is associated with subsequent IP and PP, and whether catch-up growth in height in boys born SGA is associated with IP or PP in early adulthood. METHODS The Swedish Birth Register, held by


the National Board of Health and Welfare, was started in 1973 and contains data on >99% of all births in Sweden (21). The registry includes data on maternal demographics, reproductive


history, and complications during pregnancy, delivery, and the neonatal period. All births and deaths are validated every year against another central population register, using the


mothers' and the infants' unique personal identification numbers, assigned to each Swedish resident at birth. The Swedish Conscript Register includes information about Swedish


males conscripted for military service. Conscription is mandatory and enforced by law. Most men are conscripted at 18–25 y of age. Those with known severe handicaps, congenital


malformations, or chronic diseases are not conscripted (about 2.4% in each birth cohort). THE STUDIED COHORT. The Swedish Birth Register comprised information on 312,159 liveborn male


infants in the period from 1973 to 1978. To increase the homogeneity of the study population, we excluded multiple births, congenital malformations, and infants born to non-Nordic mothers.


In all, we included 279,435 males, of whom 3,402 died before 18 y of age. The remaining 276,033 males constitute the study population, of whom 21,607 (7.8%) were not conscripted between


January 1991 and January 1997. Of 254,426 conscripted males, data on IP and PP were available in 248,051 (97%) and 230,988 (91%) males, respectively. Information about birth weight, birth


length, and head circumference was obtained from the Swedish Birth Register. Gestational age was estimated from the date of the last menstrual period and stratified into very preterm (≤31


wk), moderately preterm (32–36 wk), term (37–41 wk), and post-term (≥42 wk) births. Birth weight and length were analyzed both as continuous and categorical variables with similar results.


The results are presented using categorical variables to simplify the presentation. Birth weight for gestational age was divided into three categories: light for gestational age, defined as


>2 SDS below mean birth weight for gestational age; appropriate weight for gestational age, defined as birth weight between −2 and +2 SDS; and heavy for gestational age, defined as birth


weight >2 SDS above the mean. Birth length for gestational age and head circumference were defined analogously (22). SGA was defined as less than −2 SDS in either birth length or weight


for gestational age, and divided into three different subgroups: born short only, born light only, and born both short and light for gestational age. The cutoff at −2 SDS is commonly used to


define small size for gestational age. Children shorter than −2 SDS are also those in whom investigation for growth hormone deficiency may be considered. Linear catch-up growth was defined


as being born SGA and being above −2 SDS in height at conscription. DEPENDENT VARIABLES. At conscription, all the men undergo a thorough health examination, including height and weight


measurements, and a number of tests. The information is computerized and the personal identification number of each subject ensures individual record linkage to other information sources.


General IP is measured by a time-limited test package including four dimensions: logical/inductive, verbal, spatial, and theoretical/technical. The test questionnaire contains 160 items, 40


from each dimension, and has been computerized since 1994 (16). The direct interaction with computerized test programs avoids the risk for observer bias to, for example, short people. PP


during mental stress is also evaluated. The evaluation is performed using semistructured interviews by specialized psychologists with the aim of measuring how the conscript might be able to


manage difficult situations during stress. The results are acknowledged to reflect different aspects of personality. The results on IP and PP are presented as standard nine (stanine) scores


(mean = 5, SD = 2). Subnormal performance was defined as a score of ≤3 (_i.e._ less than −1 SD). The 10% scoring ≤2 in IP can be expected to have difficulties in ordinary basic education


programs, and the 20% scoring ≤3 cannot be expected to be successful in higher education. STATISTICAL METHODS. Analyses were performed using bivariate and multiple logistic and linear


regression analyses. OR are presented with 95% CI within parentheses. The standard statistical package SPSS for Windows (version 10.0, SPSS, Chicago, IL, U.S.A.) was used in the statistical


calculations. The study was approved by the Ethics Committee of the Medical Faculty of Uppsala University. RESULTS In the analyzed cohort of conscripted young men, 0.3% were born very


preterm (≤31 wk), and 4.0% were born moderately preterm (32–36 wk). In all, 2.6% were born light for gestational age, and 2.5% were short for gestational age. In relation to the reference


population (22), there was a slightly increased number of newborns above +2 SDS in birth length and weight (3.4% and 2.7%, respectively). Males born below −2 SDS in length for gestational


age had a lower mean IP score than those born above −2 SDS, and similar patterns were seen when analyzing birth weight and head circumference (Table 1). Males born preterm, especially those


born very preterm, had lower mean IP scores than those born at term or post-term. Mean IP consistently increased with height at conscription. Compared with those born with normal birth


characteristics, those born short, light, or with small head circumference had increased risks of subnormal IP. The highest increased risk, though, was among those born very preterm compared


with those born term, and among those who were short at conscription compared with those with a normal adult height. In the multivariate analyses, these risks were slightly attenuated, but


remained significantly increased. The correlation coefficient between the two outcome variables, IP and PP, was 0.36, and similar patterns as in IP were seen in PP. Males born with birth


length, birth weight, and head circumference below −2 SDS had lower mean scores in PP than males with normal birth characteristics. Moreover, as in IP, mean PP increased with gestational age


and adult stature. In bivariate analyses, men born short, light, or with small head circumferences were at increased risk of subnormal PP compared with men with normal birth size. The risk


of subnormal PP was also increased among men born preterm compared with men born at term, and among men who were short at conscription compared with those with a normal adult stature (Table


2). These risks remained significantly increased in the multivariate analysis, even though they were slightly attenuated. When the multivariate analyses were repeated after excluding adult


stature as an independent predictor, the association between birth characteristics and low IP or PP remained essentially unchanged (data not shown). We also repeated the analyses after


defining a subnormal IP and PP as scores ≤2 or ≤4, respectively, with minor changes in results (data not shown). In the evaluation of the effect of catch-up growth on IP and PP, the analyses


were restricted to the different subgroups of males born SGA. The distributions of stanine scores for IP are shown in Figure 1. Among men born SGA, low mean scores in IP were consistently


more common among those without catch-up growth than those with catch-up growth. The highest mean score among males born SGA in IP was seen in the subgroup born short with a normal adult


height, and the lowest score was obtained in the group born both short and light and still short at conscription (Table 3). Compared with males born short having a normal adult height, the


males in the SGA groups who were short at conscription had an increased risk of a subnormal score. Compared with males being only short or only light at birth, the risk of subnormal IP was


slightly increased among males being both short and light at birth. Catch-up growth was also associated with increased mean score of PP during stress in all SGA subgroups. Men born short and


light, who also were short at conscription, had the overall lowest result. Among men without catch-up growth, those born short had a better psychological score than those born light. As in


the case of IP, there was an increased risk of subnormal PP in males of all SGA subgroups if they were short at conscription, compared with males born short and having had catch-up growth


(Table 3). The patterns of distribution of stanine scores were similar to corresponding distributions for IP. SGA boys born both short and light had not only lower IP and PP scores than


other SGA infants, but also lower mean birth weight than SGA infants born light only, and a shorter birth length than SGA infants born short only (Table 4). We therefore investigated whether


the differences in test results between SGA groups were explained by differences in birth weight and length. This question was investigated by introducing birth length, birth weight, and an


interaction term, birth weight × birth length, as predictors of IP and PP in the multivariate regression models. Birth weight and length remained significant predictors in the models, but


the interaction term was not statistically significant (_p_ > 0.05). Rates of subnormal IP/PP among those born short and light were consistent with expected rates on those born short only


and those born light only (assuming a multiplicative model). DISCUSSION The results of this study show that males born SGA with catch-up growth and thus obtaining normal height at


conscription performed better in IP and PP compared with SGA males without catch-up growth. To our knowledge, there are no other studies in which the relation between catch-up growth in


height and IP has been examined. In the present study, all SGA subgroups with catch-up growth scored better than those without, and the risk of subnormal performance was increased in those


without catch-up growth. The present study was large enough to permit powerful comparisons between different subgroups of SGA; each SGA subgroup contained more than 3000 infants. Birth data


were collected prospectively, which precludes recall bias. The birth cohort studied was relatively homogeneous, consisting of nonmalformed male singletons born to Nordic mothers. Of the


studied birth cohorts, 92% were conscripted. Test results on IP and PP were available for the vast majority of the conscripts (97% for IP and 91% for PP). As military tests are considered


military secrets, open information on validity and reliability of these tests is scarce. However, we have no reason to believe that possible misclassifications of the test results should


differ with regard to birth characteristics. Neither do we suspect misclassifications in IP due to final height, as this test was entirely computer based. Information about maternal factors,


such as age, parity, smoking, socioeconomic status, and obstetrical and perinatal complications, was not included in analyses. SGA infants are at higher risk of asphyxia, which has been


considered important as a predictor of cognitive deficits in previous studies (3, 5, 8, 23–27). Socioeconomic factors are known to influence final height and morbidity. Studies in Poland


have demonstrated that, also within defined socioeconomic groups, those with tall adult stature had higher educational levels than those with short stature, suggesting that socioeconomic


factors could not explain all of the associations (28, 29). Swedish society is rather homogenous, and existing socioeconomic differences are relatively small. Only males were included in the


study, and as boys are reported to be more vulnerable than girls to intrauterine growth restriction, the interpretation of the findings should be restricted to boys (30). In the present


study, infants born SGA were classified into three subgroups—born short, born light, or born both short and light—as suggested by Albertsson-Wikland (18). Symmetrically (short and light)


growth-restricted infants are considered to have a growth disturbance during the first trimester, and infants born asymmetrically growth restricted (light for gestational age) are considered


to have a growth disturbance during the third trimester. The last group is regarded as less severely growth restricted and will more often have catch-up growth. It is believed that brain


and skeletal growth are not affected by the restriction in infants born light (31, 32). Infants born only short-for-gestational-age are a less studied group. It could be hypothesized that


these infants had a growth disturbance in the middle of gestation and thus are less severely growth restricted than those born short and light, but more severely growth restricted than those


born light only. In the present study, those being born both short and light for gestational age (symmetric) had the lowest mean score in both tests. Symmetrical SGA infants (_i.e._ born


both short and light), have often (8, 33), but not always (3), demonstrated less favorable neurodevelopmental outcome than infants born asymmetric. However, in the present investigation,


SGA-born boys being both short and light were actually shorter than males classified as born short only, and lighter as a group than males born light only. The question was therefore raised


whether the boys born both short and light constitute a specific subgroup, associated with increased risks, or whether these infants should be looked upon as just more severely growth


restricted. When controlling for birth weight, birth length, and adult stature in multivariate analyses, males born both short and light were not associated with a further increased risk of


subnormal IP and PP. The increased risk associated with being born both short and light is thus, to our understanding, just an additional effect to the risk of being short and the risk of


being light. A small head circumference was associated with an increased risk of low intellectual performance and slightly increased the risk of low PP in this study. A small head at birth


has earlier been reported to be associated with low IP (1, 26) or minor neurologic dysfunction (5). A small head circumference measured shortly after birth may be due to reduced growth


during pregnancy or due to compression during delivery. It is not possible to separate the importance of these factors based on our data. There is ample literature showing increased


neurodevelopmental risks in preterm infants, especially if they are SGA (3, 5, 27, 34). In the present study, preterm birth and SGA were independently associated with increased risk of


subnormal performance in both the intellectual and the psychological tests . Our data show that low birth weight for gestational age is associated with an increased risk of subnormal


intellectual capacity in young adulthood. They are in accordance with most (2, 3, 5, 7, 9, 23, 35), but not all (25, 36, 37), previous studies. In contrast with previous studies, we also


used birth length and catch-up growth as predictors. Independent of weight, we found that birth length is of importance for intellectual and psychological capacity, and lack of catch-up


growth was associated with a substantially increased risk of subnormal performance in both the intellectual and psychological tests. In conclusion, being short and/or light for gestational


age is associated with increased risk of subnormal IP and PP. The data strongly support the view that it is an advantage to have catch-up growth in length for males born SGA. ABBREVIATIONS *


CI: confidence interval * IP: intellectual performance * OR: odds ratio * PP: psychological performance * SDS: SD score(s) * SGA: small for gestational age REFERENCES * Harvey D, Prince J,


Bunton J, Parkinson C, Campbell S 1982 Abilities of children who were small-for-gestational-age babies. _Pediatrics_ 69: 296–300 CAS  PubMed  Google Scholar  * Calame A, Fawer CL, Claeys V,


Arrazola L, Ducret S, Jaunin L 1986 Neurodevelopmental outcome and school performance of very-low-birth-weight infants at 8 years of age. _Eur J Pediatr_ 145: 41–45 Article  Google Scholar 


* Tenovuo A, Kero P, Korvenrata H 1988 Developmental outcome of 519 small-for gestational age children at the age of two years. _Neuropediatrics_ 19: 41–45 Article  CAS  PubMed  Google


Scholar  * Walther FJ 1988 Growth and development of term disproportionate small-for-gestational age infants at the age of 7 years. _Early Hum Dev_ 18: 1–11 Article  CAS  PubMed  Google


Scholar  * Hadders-Algra M, Huisjes HJ, Touwen BC 1988 Preterm or small-for-gestational-age infants. Neurological and behavioural development at the age of 6 years. _Eur J Pediatr_ 147:


460–467 Article  CAS  PubMed  Google Scholar  * Lagerström M, Bremme K, Eneroth P, Magnusson D 1991 School performance and IQ-test scores at age 13 as related to birth weight and gestational


age. _Scand J Psychol_ 32: 316–324 Article  PubMed  Google Scholar  * Pryor J, Silva PA, Brook M 1995 Growth, development and behavior in adolescents born small-for-gestational-age. _J


Paediatr Child Health_ 31: 403–407 Article  CAS  PubMed  Google Scholar  * Goldenberg RL, DuBard MB, Cliver SP, Nelson KG, Blankson K, Ramey SL, Herman A 1996 Pregnancy outcome and


intelligence at age five years. _Am J Obstet Gynecol_ 175: 1511–1515 Article  CAS  PubMed  Google Scholar  * Strauss RS 2000 Adult functional outcome of those born small-for-gestational age:


twenty-six-year follow-up of the 1970 British Birth Cohort. _JAMA_ 283: 625–632 Article  CAS  PubMed  Google Scholar  * Tanner JM 1986 Growth as a mirror of conditions of society: secular


trends and class distinctions. In: Demirjam A, Brault Dubuc M (eds) _Human Growth: A Multidisciplinary Review_. London, Taylor and Francis Google Scholar  * MacIntyre 1988 A review of the


social patterning and significance or measures of height, weight, blood pressure and respiratory functions. _Soc Sci Med_ 27: 327–237 * Allebeck P, Bergh C 1992 Height, body mass index and


mortality: do social factors explain the association?. _Public Health_ 106: 375–382 Article  CAS  PubMed  Google Scholar  * Tanner 1966 Galtonian eugenics and the study of growth. _Eugenics


Rev_ 58: 122–135 * Humphreys LG, Davey TC, Park RK 1985 Longitudinal correlation analysis of standing height and intelligence. _Child Dev_ 56: 1465–1478 Article  CAS  PubMed  Google Scholar


  * Teasdale TW, Owen DR, Sörensen TIA 1991 Intelligence and educational level in adult males at the extremes of stature. _Hum Biol_ 63: 19–30 CAS  PubMed  Google Scholar  * Tuvemo T,


Jonsson B, Persson I 2000 Intellectual and physical performance and morbidity in relation to height in a cohort of 18-year-old Swedish conscripts. _Horm Res_ 52: 186–191 Google Scholar  *


Leger J, Limoni C, Collin D, Czernichow P 1998 Prediction factors in the determination of final height in subjects born small for gestational age. _Pediatr Res_ 43: 808–812 Article  CAS 


PubMed  Google Scholar  * Albertssson-Wikland Karlberg J 1994 Natural growth in children born small for gestational age with and without catch-up growth. _Acta Paediatr Suppl_ 399: 64–70


Article  Google Scholar  * Tuvemo T, Cnattingius S, Jonsson B 1999 Prediction of male adult stature using anthropometric data at birth: a nationwide population-based study. _Pediatr Res_ 46:


491–495 Article  CAS  PubMed  Google Scholar  * Eriksson JG, Forsen T, Tuomilehto J, Winter PD, Osmond C, Barker DJ 1999 Catch-up growth and death from coronary heart disease: longitudinal


study. _BMJ_ 318: 427–431 Article  CAS  PubMed  PubMed Central  Google Scholar  * Cnattingius S, Ericson A, Gunnarskog J, Källén B 1990 A quality study of a medical birth registry. _Scand J


Soc Med_ 18: 143–148 Article  CAS  PubMed  Google Scholar  * Niklasson A, Ericson A, Fryer JG, Karlberg J, Lawrence C, Karlberg P 1991 An update of the Swedish reference standards for


weight, length and head circumference (1977–1981). _Acta Paediatr Scand_ 80: 756–762 Article  CAS  PubMed  Google Scholar  * Sørensen HT, Sabroe S, Olsen J, Rothman KJ, Gillman MW, Fischer P


1997 Birth weight and cognitive function in young adult life: historical cohort study. _BMJ_ 315: 401–403 Article  PubMed  PubMed Central  Google Scholar  * Westwood M, Kramer MS, Munz D,


Lovett JM, Watters GV 1983 Growth and development of full-term non-asphyxiated small-for-gestational-age newborns: follow-up through adolescence. _Pediatrics_ 71: 376–382 CAS  PubMed  Google


Scholar  * Fattal-Valevski A, Leitner Y, Kutai M, Tal-Posener E, Tomer A, Lieberman D, Jaffa A, Many A, Harel S 1999 Neurodevelopmental outcome in children with intrauterine growth


restriction: a 3-year follow-up. _J Child Neurol_ 14: 724–727 Article  CAS  PubMed  Google Scholar  * Gross SJ, Kosmetatos N, Grimes CT, Williams ML 1978 Newborn head size and neurological


status. Predictors of growth and development of low birth weight. _Am J Dis Child_ 132: 753–756 Article  CAS  PubMed  Google Scholar  * Martikainen M 1992 Effects of intrauterine growth


retardation and its subtypes on the development of the preterm infant. _Early Hum Dev_ 28: 7–17 Article  CAS  PubMed  Google Scholar  * Bielicki T, Charzewski J 1983 Body height and upward


social morbidity. _Ann Hum Biol_ 5: 403–408 Article  Google Scholar  * Bielicki T, Waliszko H 1992 Stature, upward social mobility and the nature of statural differences between social


class. _Ann Hum Biol_ 19: 589–593 Article  CAS  PubMed  Google Scholar  * Neligan GA, Kolvin I, Scott DM, Garside RF 1976 Born Too Soon or Born Too Small. A Follow-up Study to Seven Years of


Age. Clinics in Developmental Medicine, No. 61. pp 35–53 Heineman, London * Prada JA 1998 Biological mechanisms or environmentally induced causes of IUGR. _Eur J Clin Nutr_ S21–S27 *


Wollmann HA 1998 Intrauterine growth restriction: definition and etiology. _Horm Res_ 2: 1–6 Article  Google Scholar  * Villar J, Smeriglio V, Martorell R, Brown CH, Klein RE 1984


Heterogeneous growth and mental development of intrauterine growth-restricted infants during the first 3 years of life. _Pediatrics_ 74: 783–791 CAS  PubMed  Google Scholar  * Matilainen R,


Heinonen K, Siren-Tiusanen H 1988 Effect of intrauterine growth restriction (IUGR) on the psychological performance of preterm children at preschool age. _J Child Psychol Psychiatry_ 29:


601–609 Article  CAS  PubMed  Google Scholar  * Low JA, Handley-Derry MH, Burke SO, Peters RD, Pater EA, Killen HL, Berrick EJ 1992 Association of intrauterine fetal growth retardation and


learning deficits at the age of 9 to 11 years. _Am J Obstet Gynecol_ 167: 1499–1505 Article  CAS  PubMed  Google Scholar  * Nilsen ST, Finne PH, Bergsjo P, Stamnes O 1984 Males with low


birth weight examined at 18 years of age. _Acta Paediatr Scand_ 73: 168–175 Article  CAS  PubMed  Google Scholar  * Hawdon JM, Hey E, Kolvin I, Fundudis T 1990 Born too small—is the outcome


still affected?. _Dev Med Child Neurol_ 32: 943–953 Article  CAS  PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS The authors thank the National Service Administration of Sweden


for making the data available. We also thank their chief psychologist, Johan Lothigius, National Service Administration of Sweden. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department


of Women's and Children's Health, Uppsala University, Uppsala, Sweden Ester Maria Lundgren & Torsten Tuvemo * Departments of Medical Epidemiology, Karolinska Institute,


Stockholm, Sweden Sven Cnattingius * Women's and Children's Health, Karolinska Institute, Stockholm, Sweden Björn Jonsson Authors * Ester Maria Lundgren View author publications


You can also search for this author inPubMed Google Scholar * Sven Cnattingius View author publications You can also search for this author inPubMed Google Scholar * Björn Jonsson View


author publications You can also search for this author inPubMed Google Scholar * Torsten Tuvemo View author publications You can also search for this author inPubMed Google Scholar


CORRESPONDING AUTHOR Correspondence to Torsten Tuvemo. ADDITIONAL INFORMATION Supported, in part, by Pharmacia Corporation. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE


CITE THIS ARTICLE Lundgren, E., Cnattingius, S., Jonsson, B. _et al._ Intellectual and Psychological Performance in Males Born Small for Gestational Age With and Without Catch-Up Growth.


_Pediatr Res_ 50, 91–96 (2001). https://doi.org/10.1203/00006450-200107000-00017 Download citation * Received: 25 September 2000 * Accepted: 12 February 2001 * Issue Date: 01 July 2001 *


DOI: https://doi.org/10.1203/00006450-200107000-00017 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable


link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative