80 effect of indomethacin on cerebral oxidised cytochrome aa3 concentration in preterm infants

ABSTRACT Using near infrared spectroscopy (NIRS) we have shown previously that the intravenous administration of indomethacin for treatment of patent ductus arteriosus (PDA) in sick preterm

infants caused a reduction of approximately 40% in cerebral oxygen delivery1. We have used NIRS to investigate the effect of this change on the cerebral concentration of oxidised cytochrome

aa3 ((CytO2]), the terminal enzyme in the mitochondrial electron transport chain. Studies by NIRS were performed on 15 infants born at 23-29 weeks gestation weighing 600-1620 grams, who

required treatment for PDA aged 8-27 days. Infants received indomethacin 0.1-0.2 mg.kg−, seven by fast (30 sees) and eight by slow (30 mins) infusion. The expected haemodynamic changes were

seen in all infants. In 5 infants an unequivocal fall in [CytO2] was observed (range 0.3-0.9 μmol.1−), while the remaining 10 infants showed no definite change. No significant difference

between the fast and slow infusion was observed. We conclude that following indomethacin the close relationship between cerebral intracellular oxygen supply and cerebral energy metabolism

was frequently maintained, but in 5 cases there was evidence of a relative intracellular oxygen deficit. 1. AD Edwards et al. Pediatr Res 1989:26:522 ARTICLE PDF AUTHOR INFORMATION AUTHORS

AND AFFILIATIONS * Depts of Paediatrics, and Medical Physics and Bioengineering, University College and Middlesex School of Medicine, London D C McCormick, A D Edwards, J S Wyatt, A Potter, 

M Cope, D T Delpy & E O R Reynolds Authors * D C McCormick View author publications You can also search for this author inPubMed Google Scholar * A D Edwards View author publications You

can also search for this author inPubMed Google Scholar * J S Wyatt View author publications You can also search for this author inPubMed Google Scholar * A Potter View author publications

You can also search for this author inPubMed Google Scholar * M Cope View author publications You can also search for this author inPubMed Google Scholar * D T Delpy View author publications

You can also search for this author inPubMed Google Scholar * E O R Reynolds View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE McCormick, D., Edwards, A., Wyatt, J. _et al._ 80 Effect of indomethacin on cerebral oxidised cytochrome aa3 concentration in

preterm infants. _Pediatr Res_ 28, 290 (1990). https://doi.org/10.1203/00006450-199009000-00104 Download citation * Issue Date: 01 September 1990 * DOI:

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