10 cerebrovascular response to hypocapnia in hypotensive newborn piglets

ABSTRACT It has been suggested that hypocapnia (which normally produces cerebral vasoconstriction) may be a cause of periventricular leukomalacia. This study tested the hypothesis that

hypocapnia superimposed upon hypotension produces a further reduction in cerebral blood flow velocity (CBFV). In 12 newborn piglets, CBFV was measured continuously through an artificial

fontanelle. Hypotension was induced by removing 30 ml/kg of blood over 30 minutes. Increasing the ventilator rate from 20 to 100/m min reduced the average pCO2 from above 5.0 to below 2.0

kPa. When mean arterial pressure (MAP) was held steady at 45 mm Hg or above, hypocapnia produced a signficant drop in CBFV but, in all the piglets with a steady MAP below 38 mm Hg,

hypocapnia failed to change CBFV. Jugular vein or sagital sinus blood showed no increase in hypoxanthine during hypocapnia. Hyperventilation (without haemorrhage) produced a signficant drop

in MAP, preventable by infusing colloid. Hypocapnia itself does not further reduce CBFV in the hypotensive piglet. However, the pressure effect of hyperventilation may significantly impair

the cerebral circulation. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Depts of Paediatrics & Anaesthesia, Ullevål Hospital, Oslo, Norway Andrew Whitelaw, Bente Karlsen, 

Kirsti Haaland, Petter Andreas Steen & Marianne Thoresen Authors * Andrew Whitelaw View author publications You can also search for this author inPubMed Google Scholar * Bente Karlsen

View author publications You can also search for this author inPubMed Google Scholar * Kirsti Haaland View author publications You can also search for this author inPubMed Google Scholar *

Petter Andreas Steen View author publications You can also search for this author inPubMed Google Scholar * Marianne Thoresen View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Whitelaw, A., Karlsen, B., Haaland, K. _et al._ 10 CEREBROVASCULAR RESPONSE TO

HYPOCAPNIA IN HYPOTENSIVE NEWBORN PIGLETS. _Pediatr Res_ 28, 278 (1990). https://doi.org/10.1203/00006450-199009000-00034 Download citation * Issue Date: 01 September 1990 * DOI:

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