Effects of digoxin on diaphragmatic contractility in the piglet

ABSTRACT ABSTRACT: Minute ventilation, arterial blood gases and pH, cardiac output, and transdiaphragmatic force generation were measured in eight anesthetized, tracheostomized piglets

before and after administration of 40 µg/kg body wt of digoxin. No changes were noted in cardiac output, heart rate, tidal vol, respiratory rate, or minute ventilation. Blood pressure

decreased from baseline to 60 min postinfusion. No change was noted in the force frequency curves at 30 and 60 min postinfusion. Serum digoxin levels averaged 10.4 ng/mL at 30 min and 5.6

ng/mL at 60 min. In seven control animals, no changes were noted in any ventilatory or hemodynamic parameter from baseline to 60 min. In contrast to the reported effects of digoxin on the

diaphragm of adult humans and animals, digoxin did not augment diaphragmatic contractility in normal infant swine. SIMILAR CONTENT BEING VIEWED BY OTHERS SYNCHRONIZED AND PROPORTIONAL

SUB-DIAPHRAGMATIC UNLOADING IN AN ANIMAL MODEL OF RESPIRATORY DISTRESS Article 08 August 2022 EVALUATION OF ELECTRIC PHRENIC NERVE STIMULATION PATTERNS FOR MECHANICAL VENTILATION: A PILOT

STUDY Article Open access 12 July 2023 ROUTINE HYPERCAPNIC CHALLENGE AFTER CERVICAL SPINAL HEMISECTION AFFECTS THE SIZE OF PHRENIC MOTONEURONS Article Open access 25 August 2023 ARTICLE PDF

AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, Division of Neonatal and Respiratory Diseases, University of Washington School of Medicine, Seattle, 98195, Washington

Dennis E Mayock, Thomas A Standaert & David E Woodrum Authors * Dennis E Mayock View author publications You can also search for this author inPubMed Google Scholar * Thomas A Standaert

View author publications You can also search for this author inPubMed Google Scholar * David E Woodrum View author publications You can also search for this author inPubMed Google Scholar

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Mayock, D., Standaert, T. & Woodrum, D. Effects of Digoxin on Diaphragmatic Contractility in the

Piglet. _Pediatr Res_ 25, 271–273 (1989). https://doi.org/10.1203/00006450-198903000-00010 Download citation * Received: 01 August 1988 * Accepted: 31 October 1988 * Issue Date: 01 March

1989 * DOI: https://doi.org/10.1203/00006450-198903000-00010 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative