FECAL CYTOTOXIN ON VERO CELLS (VT) AND CIRCULATING VT1 ANTIBODIES IN THE IDIOPATHIC HEMOLYTIC UREMIC SYNDROME (HUS), COMPARED WITH FAMILY MEMBERS LIVING TOGETHER (FM) AND CONTROLS WITH FAMILY DIARRHEA (C)
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Between January and July 1988, 14 children with HUS, 28 FM and 12 C were investigated. Mean age of HUS was, 11.9 months(3 - 36) and of C, 7.5 months (3-15). In both groups sex distribution
was 50%. The prodromal illness in HUS was characterized by diarrhea in 100%, bloody stools in 85.7% and upperrespiratory tract symptoms in 21.4%.
Laboratory data in HUS and C respectively were: hematocrit 22% (13-29) and 34 (28-41); leukocytes, 23,170 (8,800-91,000) and 10,700 (7,800-14,300). Platelet count, 92,000 (10,000-200,000)
and 287,000 (170,000-650,000); blood urea, 161mg% (40-290) and 22 (10-61); serum creatinine, 3.5mg% (0.8-7.8) and 0.54 (0.45-0.81). In HUS red blood cell transfusion and peritoneal dialysis
was respectively required in 78.6% and 42.9% of the cases.
First samples were obtained in HUS at mean of 9.6 days (4-27) and in C at 5.8 days (2-16) after the onset of acute diarrhea. 42.8% of HUS and none of C had reveived previous antibiotic
treatment.
Fecal VT was detected in 10 HUS (71.4%) in 4 FM (14.3%) and in 1 C (8.3%; p