7 comparison of reticulin (ara) and endomysium (ema) antibodies in coeliac disease

ABSTRACT IgA class ARA and EMA are both suggested to be good indicators of villous atrophy in coeliac disease (CD). We have now done the tests parallelly in children with untreated CD (52),

on gluten-free diet (20) and during gluten challenge (10). Children (50) biopsied because of suspected CD and with normal mucosa served as controls. Furthermore 100 adult blood donors were

tested. Children with untreated CD were both ARA and EMA positive (titres 1:10 to 1:8000 for both). 5 children with IgA deficiency and flat intestinal mucosa were negative for both tests.

During gluten-free diet disappearance of both ARA and EMA correlated well with mucosal recovery. 4 children with normal mucosa were found to have these antibodies in titres 1:5 to 1:200.

They all were brothers and sisters to CD patients. All the others were ARA and EMA negative. One of the blood donors was positive for both tests. On biopsy, subtotal villous atrophy was

found. The absorption of antibodies from patient sera with animal and human tissues and retesting results suggest the antigens for ARA and EMA not to be fully identical. However, in clinical

practise no difference between ARA and EMA could be seen. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Microbiology and Paediatrics, University Central Hospital

of Tampere, Finland and Hospital Infantil “La Paz”, Madrid, Spain M Mäki, O Hällström, I Polanco & J K Visakorpi Authors * M Mäki View author publications You can also search for this

author inPubMed Google Scholar * O Hällström View author publications You can also search for this author inPubMed Google Scholar * I Polanco View author publications You can also search for

this author inPubMed Google Scholar * J K Visakorpi View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions

ABOUT THIS ARTICLE CITE THIS ARTICLE Mäki, M., Hällström, O., Polanco, I. _et al._ 7 COMPARISON OF RETICULIN (ARA) AND ENDOMYSIUM (EMA) ANTIBODIES IN COELIAC DISEASE. _Pediatr Res_ 24, 406

(1988). https://doi.org/10.1203/00006450-198809000-00030 Download citation * Issue Date: 01 September 1988 * DOI: https://doi.org/10.1203/00006450-198809000-00030 SHARE THIS ARTICLE Anyone

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