Spontaneous variations in renal handling of uric acid: 164

ABSTRACT Spontaneous variations in renal handling of uric acid (UA) were studied in 8 normal male volunteers (age : 32.5 ± 4.6, BW : 68 ± 8 kg, H : 175 ± 6 cm). Over 10 weeks, urine was

collected every 12 hours for 6 consecutive days, then once every 2 weeks and blood (b) was drawn at day 1, 5 then every 2 weeks for measurement of night (n) and daytime (d) UA excretion (UA

e micromol/min), blood concentration (b UA, micromol/1), fractionnal clearance (f Cl : cl UA/GFR) and intraindividual coefficient of variation (ICV = sd/m) Over the range of observed b UA,

UA e was positively correlated with filtered UA (= 1.88 + .04 f UA, r = .60, p < .001), f Cl was correlated negatively with b UA (= .007 + 30.27/b UA, r = .69, p < .001) and positively

with f Cl for sodium (p < .05), suggesting that spontaneous variations of b UA are partly due to changes in net renal transport of UA and dependent on sodium status. Conclusion : These

variations should be taken in account when evaluating the effect of drugs interfering with UA metabolism. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Clinique de Néphrologie,

INSERM U 80, Hôpital Edouard Herriot, LYON, France N Pozet, M Labeeuw, A Hadj Aissa, J Sassard & P Zech Authors * N Pozet View author publications You can also search for this author

inPubMed Google Scholar * M Labeeuw View author publications You can also search for this author inPubMed Google Scholar * A Hadj Aissa View author publications You can also search for this

author inPubMed Google Scholar * J Sassard View author publications You can also search for this author inPubMed Google Scholar * P Zech View author publications You can also search for this

author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Pozet, N., Labeeuw, M., Aissa, A. _et al._ SPONTANEOUS VARIATIONS IN

RENAL HANDLING OF URIC ACID: 164. _Pediatr Res_ 19, 771 (1985). https://doi.org/10.1203/00006450-198507000-00184 Download citation * Issue Date: 01 July 1985 * DOI:

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