1134 studies of safety and immunogenicity of haemophilus influenzae type b polysaccharide diphtheria toxoid conjugate vaccine (prp-d) in children 7–14 months of age

ABSTRACT In a multicenter study, 502 normal infants ages 7-14 months were randomized to receive either 2 doses of PRP-D intramuscularly containing 20 ug PRP (80%) or placebo (20%) 6-10 weeks

apart. Serum samples were obtained from 25% prior to each injection and 1 month post second dose and tested by Farr-type radioimmunoassay for anti-PRP antibody. Reaction data are available

from 400 subjects. The incidence of local erythema at the injection site was 2.4% and irritability 3% in both groups. Two PRP-D recipients had temperatures greater than 1022(R). Among 120

children tested for antibody, 99% of PRP-D recipients demonstrated a two fold or greater rise in anti-PRP compared with 5% of placebo recipients. Median anti-PRP levels in the two groups

were 7.0 and 0.012 ug/ml respectively. After 2 doses of PRP-D, 95% had ≥ 0.15 ug/ml antibody protein/ml and 90% had > 1 ug/ml. This study confirms prior observations in 9-14 month olds

that PRP-D can induce primary and booster antibody responses in infants over 7 months compatible with protection against H. influenzae b disease. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * Albany Medical College, Albany, NY Martha Lepow, Roger Barkin, Kathleen Meier, John Zahradnik, Carol Berkowitz, David James, Philip Brunell, Joel Samuelson & Lance Gordon

* U. of Colorado, Health Services Center, Denver Martha Lepow, Roger Barkin, Kathleen Meier, John Zahradnik, Carol Berkowitz, David James, Philip Brunell, Joel Samuelson & Lance Gordon *

Baylor College of Medicine, Houston Martha Lepow, Roger Barkin, Kathleen Meier, John Zahradnik, Carol Berkowitz, David James, Philip Brunell, Joel Samuelson & Lance Gordon * Harbor-UCLA

Medical Center, CA Martha Lepow, Roger Barkin, Kathleen Meier, John Zahradnik, Carol Berkowitz, David James, Philip Brunell, Joel Samuelson & Lance Gordon * Universitv of Tennessee,

Memphis Martha Lepow, Roger Barkin, Kathleen Meier, John Zahradnik, Carol Berkowitz, David James, Philip Brunell, Joel Samuelson & Lance Gordon * University of Texas, San Antonio Martha

Lepow, Roger Barkin, Kathleen Meier, John Zahradnik, Carol Berkowitz, David James, Philip Brunell, Joel Samuelson & Lance Gordon * Departments of Pediatrics, Martha Lepow, Roger Barkin, 

Kathleen Meier, John Zahradnik, Carol Berkowitz, David James, Philip Brunell, Joel Samuelson & Lance Gordon * Connaught Laboratories, Swiftwater, PA Martha Lepow, Roger Barkin, Kathleen

Meier, John Zahradnik, Carol Berkowitz, David James, Philip Brunell, Joel Samuelson & Lance Gordon * Toronto, Canada Martha Lepow, Roger Barkin, Kathleen Meier, John Zahradnik, Carol

Berkowitz, David James, Philip Brunell, Joel Samuelson & Lance Gordon Authors * Martha Lepow View author publications You can also search for this author inPubMed Google Scholar * Roger

Barkin View author publications You can also search for this author inPubMed Google Scholar * Kathleen Meier View author publications You can also search for this author inPubMed Google

Scholar * John Zahradnik View author publications You can also search for this author inPubMed Google Scholar * Carol Berkowitz View author publications You can also search for this author

inPubMed Google Scholar * David James View author publications You can also search for this author inPubMed Google Scholar * Philip Brunell View author publications You can also search for

this author inPubMed Google Scholar * Joel Samuelson View author publications You can also search for this author inPubMed Google Scholar * Lance Gordon View author publications You can also

search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lepow, M., Barkin, R., Meier, K. _et al._ 1134 STUDIES OF

SAFETY AND IMMUNOGENICITY OF HAEMOPHILUS INFLUENZAE TYPE B POLYSACCHARIDE DIPHTHERIA TOXOID CONJUGATE VACCINE (PRP-D) IN CHILDREN 7–14 MONTHS OF AGE. _Pediatr Res_ 19, 299 (1985).

https://doi.org/10.1203/00006450-198504000-01164 Download citation * Issue Date: 01 April 1985 * DOI: https://doi.org/10.1203/00006450-198504000-01164 SHARE THIS ARTICLE Anyone you share the

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