Melatonin day-night rhythms in subjects with turner syndrome

ABSTRACT The day-night rhythms of serum melatonin (MEL) were investigated in 10 subjects with Turner syndrome,aged 2-17 years.Five had karyotype 45 XO,4 had 45 XO/46 XX and one 45

XO/46XX/47XXX mosaicism.Serum MEL concentrations were determined according to the RIA procedure of Rollag and Niswander,using the antibody kindly donated by Dr. Niswander.Serum LH,FSH and

PRL were measured by routine RIAs.MEL patterns were abnormal in all subjects. 1.Day-time values were higher than normal (135±88 vs. 55±26,p < 0.05), as already observed in a previous

study (Gupta et al, 1983).2.Night peak MEL values were in the prepubertal range irrespective of the age and developmental stage of the subject. 3.Desynchronized ultradian rhythms were

present in all subjects except one,a 17-yrs. old XO/XX girl who had spontaneous menstruations. 4.No relationship between MEL serum levels and gonadotrophin concentrations were found. 5.In

some of the patients the night elevation in serum PRL levels was very pronounced. These data illustrate the principle that chromosomal abnormality may be antecedent to the development of

aberrations in relation to the pineal biorhythm.However,this is simply a hypothesis which should be examined further. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of

Diagnostic Endocrinology, and Department of Endocrinology, University Children's Hospital,7400 Tübingen, ERG, Ospedale del Bambin Gesu, Rome, Italy A Attanasio, P Borrelli, G Munding 

& D Gupta Authors * A Attanasio View author publications You can also search for this author inPubMed Google Scholar * P Borrelli View author publications You can also search for this

author inPubMed Google Scholar * G Munding View author publications You can also search for this author inPubMed Google Scholar * D Gupta View author publications You can also search for

this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Attanasio, A., Borrelli, P., Munding, G. _et al._ Melatonin day-night

rhythms in subjects with Turner Syndrome. _Pediatr Res_ 18, 1227 (1984). https://doi.org/10.1203/00006450-198411000-00157 Download citation * Issue Date: November 1984 * DOI:

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