Cell mediated immunity conferred by natural rsv infection and killed vaccine

ABSTRACT In attempts to understand the apparent “sensitization” of individuals to respiratory syncytial virus (RSV) after inactivated RSV vaccine, in vitro lymphocyte transformation studies

were carried out as a measure of cell mediated immunity in infants who had received inactivated RSV vaccine and infants who had received a similar Darainfluenza 1 virus vaccine. Some infants

in each group had, and others had not, undergone natural RSV infection prior to the lymphocyte studies. All infants who had received the RSV vaccine and/or who had undergone RSV infection

showed RSV specific lymphocyte transformation. These findings strongly suggest that svstemic RSV-specific cell mediated immunity developed after immunization with killed RSV vaccine and

after natural RSV infection. As applied to understanding the pathogenesis and prevention of RSV disease these findings: 1) are consistent with the hypothesis that systemic cell mediated

“sensitization” may be responsible for the altered response to natural infection occurring following use of inactivated RSV vaccine. 2) are opposed to the hypothesis that cell mediated

immunity per se is important in protection against RSV infection. 3) suggest the hvpothesis that transplacentally conferred lymphocyte sensitization to RSV might play a part in the

pathogenesis of first infection RSV bronchiolitis. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * George Washington University and Research Foundation of Children's Hospital,

Washington, 20009, D.C. Hyun W Kim, Sanford L Leikin, Carl P Brandt, Robert M Chanock & Robert H Parrott Authors * Hyun W Kim View author publications You can also search for this

author inPubMed Google Scholar * Sanford L Leikin View author publications You can also search for this author inPubMed Google Scholar * Carl P Brandt View author publications You can also

search for this author inPubMed Google Scholar * Robert M Chanock View author publications You can also search for this author inPubMed Google Scholar * Robert H Parrott View author

publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kim, H., Leikin, S., Brandt, C.

_et al._ CELL MEDIATED IMMUNITY CONFERRED BY NATURAL RSV INFECTION AND KILLED VACCINE. _Pediatr Res_ 8, 415 (1974). https://doi.org/10.1203/00006450-197404000-00448 Download citation * Issue

Date: 01 April 1974 * DOI: https://doi.org/10.1203/00006450-197404000-00448 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link

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