The effect of parathyroid hormone on rabbit renal cortex adenyl cyclase during development

ABSTRACT Extract: Renal cortex from fetal and neonatal rabbits (from 4–5 days preterm to 4 days of age) shows results comparable with maternal renal cortex during _in vitro_ stimulation of

the 2,200 × g pellet with parathyroid hormone (PTH) at 20 μg/ml. Incubation with sodium fluoride (10 mM), a nonspecific potent stimulator of adenyl cyclase, resulted in comparable increases

in both the fetal and the maternal renal cortex. Glucagon, prostaglandin E1, and vasopressin, all at 20 μg/ml, stimulate adenyl cyclase to a lesser extent than PTH. Homogenates of full term

neonatal rabbits and maternal renal cortex show comparable phosphodiesterase enzyme levels with or without 0.04 M imidazole. These data show that in fetal and early neonatal renal cortex

there is no developmental adenyl cyclase responsiveness to PTH. Similarly, phosphodiesterase is present equally in term and maternal rabbit renal cortex. Speculation: A maturational response

of adenosine 3′,5′-monophosphate (cyclic AMP) in urine to PTH has been previously suggested in the human full term neonate. This change in responsiveness may not be due to a defect in the

PTH hormone receptor or the adenyl cyclase enzyme of the proximal renal tubule. Other causes, such as impaired proximal tubular transport of cyclic AMP, may account for this maturational

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OF ALDOSTERONE EXCESS AND IN HUMAN PRIMARY ALDOSTERONISM Article Open access 29 July 2021 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, Mercy Hospital

and Children's Hospital of the University of Pittsburgh, Pittsburgh, Pennsylvania, USA Louie G Linarelli, John Bobik & Caroline Bobik Authors * Louie G Linarelli View author

publications You can also search for this author inPubMed Google Scholar * John Bobik View author publications You can also search for this author inPubMed Google Scholar * Caroline Bobik

View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Linarelli, L.,

Bobik, J. & Bobik, C. The Effect of Parathyroid Hormone on Rabbit Renal Cortex Adenyl Cyclase during Development. _Pediatr Res_ 7, 878–882 (1973).

https://doi.org/10.1203/00006450-197311000-00003 Download citation * Issue Date: 01 November 1973 * DOI: https://doi.org/10.1203/00006450-197311000-00003 SHARE THIS ARTICLE Anyone you share

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Nature SharedIt content-sharing initiative KEYWORDS * Adenyl cyclase * fetus * kidney * newborn * parathyroid hormone * prostaglandin E1 * vasopressin