Effects of human growth hormone (hgh) on 79 hypopituitary children

ABSTRACT We have treated 58 idiopathic (IH) and 16 organic hypopituitary (OH) children for 12 months, using 5 treatment regiments, in order to determine optimum therapy with HGH and

glucocorticoids. All patients had: growth hormone levels < 5 mμg/ml plasma during insulin induced hypoglycemia; bone ages of 12 years or less; sexual infantilism. In IH, height wa −4 SD

or further below the mean. In OH, pretreatment growth rate was below 2.5 cm/year. Listed are 5 treatment regimens and growth rates during therapy. _Conclusions:_ HGH stimulated linear growth

of hypopituitary children to varying degrees; more effectively in younger smaller dwarfs, less effectively in the older larger or cortisone treated dwarfs. HGH from embalmed bodies is

clinically useful. HGH, 10 U., was not more beneficial than 2 U. The craniopharyngiomas in the OH did not grow during short-term treatment with HGH. ARTICLE PDF AUTHOR INFORMATION AUTHORS

AND AFFILIATIONS * Depts. of Ped., Med., Rad., SUNY, Buffalo Thomas Aceto Jr., Alvin B Hayles, Mary L Parker, S Douglas Frasier, Richard W Munschauer & Giovanni Di Chiro * Univ. of

Minn., Rochester Thomas Aceto Jr., Alvin B Hayles, Mary L Parker, S Douglas Frasier, Richard W Munschauer & Giovanni Di Chiro * Washington Univ., St. Louis Thomas Aceto Jr., Alvin B

Hayles, Mary L Parker, S Douglas Frasier, Richard W Munschauer & Giovanni Di Chiro * USC, L.A. Thomas Aceto Jr., Alvin B Hayles, Mary L Parker, S Douglas Frasier, Richard W Munschauer 

& Giovanni Di Chiro * NIH, Bethesda, Md Thomas Aceto Jr., Alvin B Hayles, Mary L Parker, S Douglas Frasier, Richard W Munschauer & Giovanni Di Chiro Authors * Thomas Aceto Jr. View

author publications You can also search for this author inPubMed Google Scholar * Alvin B Hayles View author publications You can also search for this author inPubMed Google Scholar * Mary L

Parker View author publications You can also search for this author inPubMed Google Scholar * S Douglas Frasier View author publications You can also search for this author inPubMed Google

Scholar * Richard W Munschauer View author publications You can also search for this author inPubMed Google Scholar * Giovanni Di Chiro View author publications You can also search for this

author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Aceto, T., Hayles, A., Parker, M. _et al._ Effects of Human Growth Hormone

(HGH) on 79 Hypopituitary Children. _Pediatr Res_ 4, 459–460 (1970). https://doi.org/10.1203/00006450-197009000-00101 Download citation * Issue Date: 01 September 1970 * DOI:

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