Design of RNA-Binding Oligopeptides Based on Information of RNA-Binding Protein

In this study, we demonstrated the methodology to design RNA-recognizing oligopeptides. The sequences of the oligopeptides were selected from the information of polypyrimidine tract binding

protein (PTB). The oligoRNA sequence was chosen from the hepatitis C virus internal ribosome entry site (HCV IRES) region, where PTB is supposed to interact. The interaction between the

oligopeptides and oligoRNA was examined by UV, fluorescence, and circular dichroism (CD) spectroscopy. Oligopeptides which can interact with oligoRNA in a specific manner were explored.

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