Molecular weight and conformation of poly(s-[(3-hydroxypropyl)-carbamoylmethyl]-l-cysteine) in various solvents

ABSTRACT The number-average and weight-average molecular weights of seven samples of poly(_S_-[(3-hydroxypropyl)-carbamoylmethyl]-L-cysteine) (poly(Cys[CamPrOH])) have been determined by

measurements of osmotic pressure of 0.1% CH3COOH solutions and light scattering of hexafluoro-2-propanol solutions, respectively. A strong tendency of poly(Cys[CamPrOH]) to form the

β-conformation is observed in various solvents, including CH3COOH–H2O, DCA, H2O, and D2O. When dissolved in H2O at 70°C, poly(Cys[CamPrOH]) having molecular weight lower than 18,000 is

randomly coiled and that having molecular weight higher than 20,000 is subject to the thermally-induced β-coil transition. When dissolved in D2O at 70°C, poly(Cys[CamPrOH]) undergoes the

thermally-induced β-coil transition, irrespective of the molecular weight. D2O stabilizes the β-conformation more effectively than does H2O, by the change in the structure of water rather

than by the substitution of D for H on the polypeptide. SIMILAR CONTENT BEING VIEWED BY OTHERS CONONSOLVENCY OF POLY(CARBOXYBETAINE METHACRYLATE) IN WATER–ETHANOL MIXED SOLVENTS Article 25

April 2023 EFFECT OF INTRAMOLECULAR HYDROGEN-BOND FORMATION ON THE MOLECULAR CONFORMATION OF AMINO ACIDS Article Open access 30 June 2020 POLYMERIZATION OF EXPANDED L-AMINO ACIDS CONTAINING

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AFFILIATIONS * Department of Chemistry, Faculty of Science, Nagoya University, Shoichi Ikeda & Tetsuo Tomiyama Authors * Shoichi Ikeda View author publications You can also search for

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ABOUT THIS ARTICLE CITE THIS ARTICLE Ikeda, S., Tomiyama, T. Molecular Weight and Conformation of Poly(_S_-[(3-hydroxypropyl)-carbamoylmethyl]-L-cysteine) in Various Solvents. _Polym J_ 14,

33–42 (1982). https://doi.org/10.1295/polymj.14.33 Download citation * Issue Date: 01 January 1982 * DOI: https://doi.org/10.1295/polymj.14.33 SHARE THIS ARTICLE Anyone you share the

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Nature SharedIt content-sharing initiative KEYWORDS * Poly(_S_-[(3-hydroxypropyl)-carbamoylmethyl]-L-cysteine * β-Conformation * β-Coil Transition * Molecular Weight * Hexafluoro-2-propanol

* Deuterium Oxide * Osmotic Pressure * Light Scattering * Circular Dichroism