Androgen and ar contribute to breast cancer development and metastasis: an insight of mechanisms

Androgen and ar contribute to breast cancer development and metastasis: an insight of mechanisms


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ABSTRACT The role of androgen and androgen receptor (AR) in breast carcinogenesis has long been a disputed issue. This report provides a mechanistic insight into how androgen and AR


contributes to invasion and metastasis of breast cancer. We find that dihydrotestosterone (DHT) is able to induce the epithelial-to-mesenchymal transition in breast cancer cells in an


AR-dependent/estrogen receptor-independent manner. This process is dependent on the demethylation activity of lysine-specific demethylase 1A (LSD1) by epigenetically regulating the target


genes E-cadherin and vimentin. _In vivo_, DHT promotes metastasis in a nude mouse model, and AR and LSD1 are indispensable in this process. We establish that higher expression of nucleus AR


to cytoplasm AR associated with worse prognostic outcomes in breast cancer patient samples. This study maps an ‘androgen-AR/LSD1-target genes’ pathway in breast carcinogenesis, implicating


the importance of hormonal balance in women, and the potential clinical significance of serum androgen and AR in prediction of breast cancer and selection of breast cancer therapy. Access


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of print 8 February 2015doi:10.3791/51967. Download references ACKNOWLEDGEMENTS We thank Dr Wei Huang from School of Mathematics and Statistics of Northeast Normal University for kindly


providing statistical analysis guidance. This work was supported by the grants from the National Natural Science Foundation of China (Grant numbers 31570718, 31571478, 31571317 and


31371294), and a grant from The University S & T Innovation Platform of Jilin Province for Economic Fungi (#2014B-1). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * The Key Laboratory of


Molecular Epigenetics of Ministry of Education (MOE), Northeast Normal University, Changchun, China J Feng, L Li, J Liu, Y Zhang & B Huang * Department of Bone and Soft Tissue Tumors,


Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China L Li * The Institute


of Genetics and Cytology, Northeast Normal University, Changchun, China N Zhang, X Li & J Lu * Department of Pathology, The Second Hospital of Jilin University, Changchun, China L Zhang 


& H Gao * National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, China G Wang & Y Li * School of Science, Auckland


University of Technology, Auckland, New Zealand D Liu Authors * J Feng View author publications You can also search for this author inPubMed Google Scholar * L Li View author publications


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can also search for this author inPubMed Google Scholar * Y Zhang View author publications You can also search for this author inPubMed Google Scholar * X Li View author publications You can


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B Huang. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. ADDITIONAL INFORMATION Supplementary Information accompanies this paper on the Oncogene website


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Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Feng, J., Li, L., Zhang, N. _et al._ Androgen and AR contribute to breast cancer development and metastasis: an insight of


mechanisms. _Oncogene_ 36, 2775–2790 (2017). https://doi.org/10.1038/onc.2016.432 Download citation * Received: 23 May 2016 * Revised: 08 October 2016 * Accepted: 19 October 2016 *


Published: 28 November 2016 * Issue Date: 18 May 2017 * DOI: https://doi.org/10.1038/onc.2016.432 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this


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