The pol ii ctd: new twists in the tail

ABSTRACT The C-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II comprises conserved heptad repeats, and post-translational modification of the CTD regulates

transcription and cotranscriptional RNA processing. Recently, the spatial patterns of modification of the CTD repeats have been investigated, and new functions of CTD modification have been

revealed. In addition, there are new insights into the roles of the enzymes that decorate the CTD. We review these new findings and reassess the role of the pol II CTD in the regulation of

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differentiation. _J. Biochem._ 160, 111–120 (2016). CAS  PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS We thank L. Vasiljeva, N. Proudfoot, M. Tellier and I. Ferrer-Vicens for

discussions and critical comments. The authors also thank F. Vazquez-Arango and M. Tellier for assistance with generating figures. This work was supported by grants from the Wellcome Trust

(WT106134A) to S.M. and by Fondation ARC to S.E. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Sir William Dunn School of Pathology, University of Oxford, Oxford, UK Justyna Zaborowska &

 Shona Murphy * Laboratoire de Biologie Moléculaire Eucaryote, CNRS, Université Paul Sabatier, Toulouse, France Sylvain Egloff Authors * Justyna Zaborowska View author publications You can

also search for this author inPubMed Google Scholar * Sylvain Egloff View author publications You can also search for this author inPubMed Google Scholar * Shona Murphy View author

publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Shona Murphy. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no

competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Zaborowska, J., Egloff, S. & Murphy, S. The pol II CTD: new twists in

the tail. _Nat Struct Mol Biol_ 23, 771–777 (2016). https://doi.org/10.1038/nsmb.3285 Download citation * Received: 07 March 2016 * Accepted: 03 August 2016 * Published: 06 September 2016 *

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