Neutrophil nets in SVV pathogenesis
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Kessenbrock, K. et al. Netting neutrophils in autoimmune small-vessel vasculitis. Nat. Med. 15, 623–625 (2009).
Anti-neutrophil cytoplasmic autoantibodies (ANCAs) against neutrophil granule proteins have a key role in the pathogenesis of small-vessel vasculitis (SVV), which results in necrotic
inflammation of small blood vessels and capillaries in affected individuals. What, though, are the mechanisms behind the pathogenic effect of these autoantibodies?
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