Waking up and down | Nature Reviews Neuroscience

Access through your institution Buy or subscribe Histaminergic neurons in the tuberomammillary nucleus (TMN) promote arousal. Many of these neurons also contain GABA, but its function in

arousal is unclear. In mice, short interfering RNA-mediated knockdown of the expression of the vesicular GABA transporter (VGAT) in TMN histaminergic neurons led to hyperactivity and

increased wakefulness. In brain slices from naive mice, optogenetic activation of histaminergic TMN neuron terminals in the neocortex and caudate putamen induced extrasynaptic GABA type A

receptor-mediated currents. These findings suggest that GABA acts in a paracrine manner to negatively modulate the effects of histamine on arousal. This is a preview of subscription content,

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OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Yu, X et al. Wakefulness is governed by GABA and histamine cotransmission.

_Neuron_ http://dx.doi.org/10.1016/j.neuron.2015.06.003 (2015) Download references Authors * Fiona Carr View author publications You can also search for this author inPubMed Google Scholar

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Carr, F. Waking up and down. _Nat Rev Neurosci_ 16, 444 (2015). https://doi.org/10.1038/nrn3995 Download

citation * Published: 08 July 2015 * Issue Date: August 2015 * DOI: https://doi.org/10.1038/nrn3995 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

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