Splicing up repair mechanisms | Nature Reviews Neuroscience

Access through your institution Buy or subscribe > in fly larvae carrying a loss-of-function mutation in Rtca, the > axons exhibited a much more robust regenerative response to damage

> in the CNS In wild-type flies, the axons of class IV dendritic arborization (da) neurons can regenerate if they are severed in the periphery, whereas limited regrowth is observed if the

axons are severed in the CNS. By damaging these axons in fly larvae, the authors aimed to identify genes that are important for axon regeneration. They found that, in fly larvae carrying a

loss-of-function mutation in _Rtca_, the axons exhibited a much more robust regenerative response to damage in the CNS. Conversely, overexpression of _Rtca_ in class IV da neurons reduced

axon regeneration after injury in the PNS, confirming that Rtca inhibits axon regeneration. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access

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subscriptions * Read our FAQs * Contact customer support REFERENCES * Song, Y. et al. Regulation of axon regeneration by the RNA repair and splicing pathway. _Nat. Neurosci._ 18, 817–825

(2015) Article  CAS  Google Scholar  Download references Authors * Katherine Whalley View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Whalley, K. Splicing up repair mechanisms. _Nat Rev Neurosci_ 16, 375 (2015). https://doi.org/10.1038/nrn3981

Download citation * Published: 03 June 2015 * Issue Date: July 2015 * DOI: https://doi.org/10.1038/nrn3981 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

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