Promoting polarity | Nature Reviews Neuroscience

Access through your institution Buy or subscribe Oligodendrocytes change shape during myelination, suggesting that correct modulation of cell polarity is essential to their function. Jarjour

_et al_. showed that the protein Scribble, an evolutionarily conserved regulator of cell polarity, is increased in mouse oligodendrocytes as they differentiate. Oligodendrocyte-specific

deletion of the gene encoding Scribble reduced developmental myelination in the CNS and impaired remyelination following a demyelinating lesion. This suggests that Scribble is an important

modulator of oligodendrocyte function during development and repair. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution

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Contact customer support REFERENCES * Jarjour, A. A. et al. The polarity protein Scribble regulates myelination and remyelination in the central nervous system. _PLoS Biol._ 13, e1002107

(2015) Article  PubMed  PubMed Central  Google Scholar  Download references Authors * Fiona Carr View author publications You can also search for this author inPubMed Google Scholar RIGHTS

AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Carr, F. Promoting polarity. _Nat Rev Neurosci_ 16, 248 (2015). https://doi.org/10.1038/nrn3960 Download

citation * Published: 15 April 2015 * Issue Date: May 2015 * DOI: https://doi.org/10.1038/nrn3960 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

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