Priming asymmetry | Nature Reviews Neuroscience

Access through your institution Buy or subscribe The differential expression of chemoreceptors in mature left ASE (ASEL) and right ASE (ASER) neurons defines their functional asymmetry, and

the transcription factors _die-1_ and _cog-1_, as well as the miRNA _lsy-6_, have been implicated in the maintenance of this asymmetric gene expression pattern. The authors show that _lsy-6_

is the first gene to be asymmetrically expressed in ASE neurons, as high levels were detected at the end of gastrulation in the mother cell of the ASEL neuron but not in that of the ASER

neuron. Further analysis revealed that two _cis_-regulatory elements are necessary for the exclusive expression of _lsy-6_ in ASEL. Whereas the _cis_-regulatory element found upstream of the

_lsy-6_ hairpin is regulated by the zinc finger transcription factor CHE-1, which is present in both mature ASE neurons, a downstream _cis_-regulatory element responds to two T-box

transcription factors, TBX-37 and TBX-38, which are only present early and transiently in the lineage that gives rise to ASEL (ABa) but not ASER (ABp). > microRNA (miRNA) priming is a key

 event in the early embryonic > stages for establishing ... functional asymmetry ... This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through

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Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Cochella, L. & Hobert, O. Embryonic priming of a miRNA locus predetermines postmitotic neuronal left/right asymmetry in

_C. elegans_. _Cell_ 151, 1229–1242 (2012) Article  CAS  Google Scholar  Download references Authors * Monica Hoyos Flight View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Flight, M. Priming asymmetry. _Nat Rev Neurosci_ 14, 78–79 (2013).

https://doi.org/10.1038/nrn3426 Download citation * Published: 19 December 2012 * Issue Date: February 2013 * DOI: https://doi.org/10.1038/nrn3426 SHARE THIS ARTICLE Anyone you share the

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