In Brief | Nature Reviews Neuroscience

Control of neurotransmitter release by an internal gel matrix in synaptic vesicles. Reigada, D. et al. Proc. Natl Acad. Sci. USA 100, 3485–3490 (2003)

In neurotransmitter vesicles from Torpedo, 95% of acetylcholine and ATP is found to be adsorbed to an intravesicular proteoglycan matrix, rather than being in free solution. This 'smart

gel', which includes the proteoglycan SV2, releases neurotransmitter in response to changes in ion concentration, and could modulate the amount of transmitter released during vesicle fusion.

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