EGL picks up its cargo | Nature Reviews Molecular Cell Biology

“...the presence of EGL in the transport complex is crucial for the efficient targeting of transcripts...”

Confirming what had previously been shown in mammalian cells, the authors show that the carboxy-terminal domain (CTD) of BICD can inhibit the minus-end-directed transport of mRNA cargo in

fly embryos. The CTD of BICD is proposed to hold the protein in an inactive conformation in the absence of cargo, by binding to the amino-terminal region. Presumably, the association of an

unknown cargo-binding protein with the CTD releases this autoinhibition of BICD, thereby stimulating mRNA transport.

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