EGL picks up its cargo | Nature Reviews Molecular Cell Biology

Access through your institution Buy or subscribe > “...the presence of EGL in the transport complex is crucial for > the efficient targeting of transcripts...” Confirming what had

previously been shown in mammalian cells, the authors show that the carboxy-terminal domain (CTD) of BICD can inhibit the minus-end-directed transport of mRNA cargo in fly embryos. The CTD

of BICD is proposed to hold the protein in an inactive conformation in the absence of cargo, by binding to the amino-terminal region. Presumably, the association of an unknown cargo-binding

protein with the CTD releases this autoinhibition of BICD, thereby stimulating mRNA transport. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access

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subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL RESEARCH PAPER * Dienstbier, M. et al. Egalitarian is a selective RNA binding protein linking mRNA localization

signals to the dynein motor. _Genes Dev_ 10 June 2009 (doi:10.1101/gad.531009) FURTHER READING * Besse, F. & Ephrussi, A. et al. Translational control of localized mRNAs: restricting

protein synthesis in space and time. _Nature Rev. Mol. Cell Biol._ 9, 971–980 (2008) Article  CAS  Google Scholar  Download references Authors * Arianne Heinrichs View author publications

You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Heinrichs, A. EGL picks up its cargo. _Nat

Rev Mol Cell Biol_ 10, 504–505 (2009). https://doi.org/10.1038/nrm2733 Download citation * Published: 01 July 2009 * Issue Date: August 2009 * DOI: https://doi.org/10.1038/nrm2733 SHARE THIS

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