Genome-wide target identification

Access through your institution Buy or subscribe Many small-molecule drugs target DNA-associated processes such as transcription, modification and replication. This paper devised a method —

called Chem-seq — based on ligand-affinity capture and massively parallel DNA sequencing to identify the genome binding sites of a bromodomain inhibitor (JQ1), a cyclin-dependent kinase 9

inhibitor (AT7519) and the DNA intercalator psoralen in multiple myeloma cells. The authors note that this method could be used to help understand the action and specificity of many small

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are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Anders, L. et al.

Genome-wide localization of small molecules. _Nature Biotech._ 32, 92–96 (2014) Article  CAS  Google Scholar  Download references Authors * Charlotte Harrison View author publications You

can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Harrison, C. Genome-wide target identification.

_Nat Rev Drug Discov_ 13, 104 (2014). https://doi.org/10.1038/nrd4248 Download citation * Published: 31 January 2014 * Issue Date: February 2014 * DOI: https://doi.org/10.1038/nrd4248 SHARE

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