Genome-wide target identification
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Access through your institution Buy or subscribe Many small-molecule drugs target DNA-associated processes such as transcription, modification and replication. This paper devised a method —
called Chem-seq — based on ligand-affinity capture and massively parallel DNA sequencing to identify the genome binding sites of a bromodomain inhibitor (JQ1), a cyclin-dependent kinase 9
inhibitor (AT7519) and the DNA intercalator psoralen in multiple myeloma cells. The authors note that this method could be used to help understand the action and specificity of many small
molecules. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online
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are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Anders, L. et al.
Genome-wide localization of small molecules. _Nature Biotech._ 32, 92–96 (2014) Article CAS Google Scholar Download references Authors * Charlotte Harrison View author publications You
can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Harrison, C. Genome-wide target identification.
_Nat Rev Drug Discov_ 13, 104 (2014). https://doi.org/10.1038/nrd4248 Download citation * Published: 31 January 2014 * Issue Date: February 2014 * DOI: https://doi.org/10.1038/nrd4248 SHARE
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