Inhibiting hippo repairs tissue

Access through your institution Buy or subscribe The Hippo signalling pathway has a pivotal role in regulating stem cell renewal, tissue regeneration and organ size control. Fan _et al_. now

describe the use of an enzyme-linked immunosorbent assay (ELISA)-based high-throughput screen of a kinase-directed compound library, to identify the benzenesulfonamide-based small molecule

XMU-MP-1 as a reversible, selective, ATP-competitive inhibitor of the mammalian Hippo orthologues, MST1 and MST2. In mice, intraperitoneal injection of XMU-MP-1 inhibited MST1/2 activities

and promoted repair and regeneration in multiple models of intestinal and liver injury. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through

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Read our FAQs * Contact customer support REFERENCES * Fan, F. et al. Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. _Sci. Transl Med._ 8,

352ra108 (2016) Article  Google Scholar  Download references Authors * Sarah Crunkhorn View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Crunkhorn, S. Inhibiting Hippo repairs tissue. _Nat Rev Drug Discov_ 15, 678 (2016).

https://doi.org/10.1038/nrd.2016.194 Download citation * Published: 29 September 2016 * Issue Date: October 2016 * DOI: https://doi.org/10.1038/nrd.2016.194 SHARE THIS ARTICLE Anyone you

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